prolonged release

prolonged release

Etymology: Gk, pro, before, longus, long
a term applied to a drug that is designed to deliver a dose of a medication over an extended period. The most common device for this purpose is a soft, soluble capsule containing minute pellets of the drug for release at different rates in the GI tract, depending on the thickness and nature of the oil, fat, wax, or resin coating on the pellets. Another system consists of a porous plastic carrier impregnated with the drug and a surfactant to facilitate the entry of GI fluids that slowly leach out of the drug. Ion exchange resins that bind to drugs and liquids containing suspensions of slow-release drug granules are also used to provide medication over an extended period. Various mechanisms and vehicles have also been developed to prolong the release of drugs after injection. Also called timed release.
References in periodicals archive ?
SRP 80 represents a new choice for customers looking to formulate prolonged release oral dosage forms with reliable performance profiles as well as robust and cost efficient production processes, which can translate into improved patient safety and compliance.
Contract awarded for code 10402 saxagliptin, metformin hydrochloride, 5 mg prolonged release tablet.
A large size is necessary for a prolonged release of the encapsulated flavor, but small beads are best for optimizing the textural and sensorial properties of foods.
The present study was aimed at design and evaluation of microspheres of highly water soluble niacin by chemical de-naturation method using chitosan as the retardant material with high entrapment efficiency and prolonged release.
Prolonged release of the hormone contributes to wide-ranging, adverse effects on a number of physiological systems.
NIGHTLY TREATMENT OF PRIMARY INSOMNIA WITH PROLONGED RELEASE MELATONIN FOR 6 MONTHS: A RANDOMIZED PLACEBO CONTROLLED TRIAL ON AGE AND ENDOGENOUS MELATONIN AS PREDICTORS OF EFFICACY AND SAFETY.
The Modern Energy Management Concept with Palatinose highlights the importance of fully digestible and low glycaemic carbohydrates for a balanced and prolonged release of energy.
TSE: 4503) today announced that Toray has obtained marketing approval for its oral PGI2 derivative prolonged release, Careload(R) LA Tablets 60mu/g (generic name: beraprost sodium), to be indicated for pulmonary arterial hypertension (PAH) on October 19,2007.
Also known as Oxycodone prolonged release, OxyContin was first licensed in the UK in 1999.
3) On the other hand, entrapped salicylic acid demonstrates decreased absorption through the skin due to its prolonged release from this compound, hence reducing skin irritation.
The expansion of the collaboration covers the co-development and marketing of products in the Amylin Pharmaceuticals portfolio, which include BYETTA([R]) (exenatide) and BYDUREON([R]) (exenatide extended-release for injectable suspension/exenatide 2 mg powder and solvent for prolonged release suspension for injection) for the treatment of type 2 diabetes, metreleptin, an investigational leptin analogue currently under review by the U.
Shire today announced that the European Commission granted Marketing Authorisation for once-daily, non-stimulant INTUNIV (guanfacine hydrochloride prolonged release tablets) for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents 6 to 17 years old for whom stimulants are not suitable, not tolerated or have been shown to be ineffective.