proliferating cell nuclear antigen


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to proliferating cell nuclear antigen: PCNA

proliferating cell nuclear antigen (PCNA),

[MIM*176740]
a nuclear nonhistone protein with a molecular weight of 36-kD that plays a role in the initiation of cell proliferation by augmenting DNA polymerase; stains for proliferating cell nuclear antigen in tumors correlated with grade and mitotic activity.

PCNA

A gene on chromosome 20pter-p12 that encodes a homotrimeric nuclear protein that is a cofactor of DNA polymerase delta. PCNA is ubiquinated in response to DNA damage and is involved in RAD6-dependent DNA repair.

pro·lif·er·at·ing cell nu·cle·ar an·ti·gen

(prō-lif'ĕr-āt'ing sel nū'klē-ĕr an'ti-jen)
A nuclear nonhistone protein with a molecular weight of 36 kD that plays a role in the initiation of cell proliferation by augmenting DNA polymerase; stains for proliferating cell nuclear antigen in tumors correlate with grade and mitotic activity.

proliferating cell nuclear antigen

Abbreviation: PCNA
A protein complex released by cells actively synthesizing DNA. In the blood, PCNAs can be used as markers of disease activity in autoimmune and inflammatory illnesses, malignancies, and other conditions marked by rapid cell replication.
See also: antigen
References in periodicals archive ?
Proliferating cell nuclear antigen and p53 indexes were defined as the percentage of cells showing positive nuclear staining with PCNA or p53, respectively.
The response of proliferating cell nuclear antigen to ionizing radiation in human lymphoblastoid cell lines is dependent on p53.
Use of proliferating cell nuclear antigen as a marker of liver regeneration after partial hepatectomy in rats.
As an alternative, a very promising noncommercial method, based on microwave heating (MWH) treatment, has recently been reported to achieve the same performance with intracellular targets [CD68, proliferating cell nuclear antigen (PCNA), Ki-67] (2).
A comparison of proliferation markers and their prognostic value for women with endometrial carcinoma, Ki-67, proliferating cell nuclear antigen, and flow cytometric S-phase fraction.
Cell proliferation markers showed an increased expression of Ki-67 (30% to 60%) and proliferating cell nuclear antigen (60% to 90%).
Even though neither proliferating cell nuclear antigen (PCNA) nor Ki-67/MIB-1 is a prognostic indicator (because proliferation is not associated with clinical outcome in CRC), Willett et al[61,62] demonstrated that small rectal tumors with high PCNA staining in preoperative biopsies responded better to radiation therapy than tumors with low proliferating indices; furthermore, they reported a significant decrease in PCNA staining in postirradiation biopsies.
Studies using proliferating cell nuclear antigen and Ki-67 have been contradictory.