Drug therapy can include antiemetics, prokinetic
agents, and proton pump inhibitors to limit acid, which slows gastric emptying.
Cisapride was developed as a "targeted" prokinetic
agent with a unique mechanism of action.
Ulimorelin is an intravenous ghrelin agonist with potent prokinetic
properties in clinical development for the treatment of gastrointestinal dysmotility conditions in acute care settings.
agents include metoclopramide and bethanechol, and the newer compounds cisapride and domperidone.
Overall, 42 of these patients resolved their cough with protonpump inhibitors alone or in combination with a prokinetic
agent; they required 26 weeks to respond.
2] blockers, and prokinetic
agents, but their effects are much swifter.
0 million nonrefundable upfront license fee received from P&G as a result of P&G's termination of their collaboration agreement with ARYx covering the company's prokinetic
Although tegaserod is approved for treating IBS with constipation, its prokinetic
effects have led to on-going studies of the drug in diabetic gastroparesis, chronic constipation, and other dysmotility syndromes.
First-line treatment for gastroparesis is a prokinetic
agent or erythromycin, Dr.
In one recent study of 12 infants, treatment with prokinetic
agents and [H.
ARYx currently has four products in clinical development: an oral anti-arrhythmic agent for the treatment of atrial fibrillation, budiodarone (ATI-2042); a prokinetic
agent for the treatment of various gastrointestinal disorders, ATI-7505; an oral anticoagulant agent for patients at risk for the formation of dangerous blood clots, tecarfarin (ATI-5923); and, an agent for the treatment of schizophrenia and other psychiatric disorders, ATI-9242.
Patients with severe gastroparesis are usually treated with nutritional support, antiemetics, and prokinetic