proinsulin


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Related to proinsulin: proinsulin C-peptide

proinsulin

 [pro-in´soo͡-lin]
a precursor of insulin, having low biologic activity.

pro·in·su·lin

(prō-in'sŭ-lin),
A single-chain precursor of insulin.

proinsulin

/pro·in·su·lin/ (-in´su-lin) a precursor of insulin, having low biologic activity.

proinsulin

(prō-ĭn′sə-lĭn)
n.
A single-chain polypeptide that is the precursor of insulin, converted into insulin by enzymatic action.

proinsulin

[prō·in′s(y)əlin]
Etymology: L, pro + insula, island
a single-chain peptide molecule that is a precursor of insulin.

INS

A gene on chromosome 11p15.5 that encodes preproinsulin, which is cleaved post-translationally into the B- and A-chain peptides (which are covalently linked via two disulfide bonds to form insulin) and C-peptide. Insulin reduces blood glucose and increases cell permeability to monosaccharides, amino acids and fatty acids, and accelerates glycolysis, the pentose phosphate cycle and glycogen synthesis in the liver.

pro·in·su·lin

(prō-in'sŭ-lin)
A single-chain precursor of insulin.

proinsulin

a precursor of insulin, having low biological activity.
References in periodicals archive ?
Our study showed increasing fasting plasma glucose, HbA1c, Total Cholesterol, total proinsulin, and insulin resistance (HOMA-IR) of [beta]-cell function.
Crucially, the misfolded mutant proteins cause normal proinsulin proteins in beta cells to misfold as well, the scientists found in studies of mouse and rat beta cells.
Researchers think it results not from a failure to convert proinsulin to insulin, but rather from an inability to transform one or more of the other proteins upon which CPE acts.
Simdiye kadar adacik antilenlerine karsi tanimlanan ve hastalik tahmin etmede faydalanilan 4 antikor bulunmaktadir: insUlin veya proinsUlin, glutamik asit dekarboksilaz 6 (GAD) veya GAD 67, insulinoma associated -2 (1A-21 veya ICA 512 veya IA-2 beta veya PHOGRIN) ve ZnT8 (10).
Since normal folding of proteins will be disrupted as a result of these mutations, formation of proinsulin is disrupted and insulin production does not occur.
It should be noted that INS-1 (832/13) cells have been stably transfected with gene encoding for human proinsulin and selected for the most robust response to glucose (Hohmeier et al.
Impaired islet [beta]-cell function is related to the loss of first-phase insulin secretion, increased proinsulin secretion, defective pulsatile insulin secretion, and the deposition of islet amyloid polypeptide (Sacks et al.
Missing ClC-3 therefore appears to cause a dramatic slowdown of the conversion of proinsulin to insulin.
You consider clozapine, but the patient has an elevated body mass index with central obesity, an elevated proinsulin level, and a hemoglobin [A.
Her C-peptide and proinsulin levels were elevated, with negative insulin antibody and negative urinary sulfonylurea levels.
BHT-3021 is a plasmid encoding proinsulin, designed to target specific pathogenic immune cells responsible for the autoimmune response in type 1 diabetic patients.
The next STELLUX[TM] products to launch will include assays for total and intact Proinsulin, C-peptide, and GLP-1.