In the carrageenan-induced air-pouch inflammation model in the rat, aspirin (150 mg/kg) or a combination of aspirin and gammaT (33 mg/kg) inhibited proinflammatory prostaglandin
E(2) (PGE(2)) by 70% (P<.
All three genetic variants are located near genes known to be involved in the pathogenesis of colon cancer, including genes that regulate the production of proinflammatory prostaglandins
and interleukins, particularly within the gut.
NSAIDs block the synthesis of proinflammatory prostaglandins
and "inhibit neoplastic proliferation by inducing apoptosis and inhibiting angiogenesis," the authors wrote.
COX-2 is the key enzyme that regulates the amount and duration of proinflammatory prostaglandins
and plays an important role in inflammation (9,10).