In the carrageenan-induced air-pouch inflammation model in the rat, aspirin (150 mg/kg) or a combination of aspirin and gammaT (33 mg/kg) inhibited proinflammatory prostaglandin
E(2) (PGE(2)) by 70% (P<.
All three genetic variants are located near genes known to be involved in the pathogenesis of colon cancer, including genes that regulate the production of proinflammatory prostaglandins
and interleukins, particularly within the gut.
COX-2 is the key enzyme that regulates the amount and duration of proinflammatory prostaglandins
and plays an important role in inflammation (9,10).
However, it was not until the 1970s that the mechanism of action was discovered; aspirin was found to inhibit the production of proinflammatory prostaglandins