prohormone


Also found in: Dictionary, Encyclopedia, Wikipedia.

prohormone

 [pro-hor´mōn]
a precursor of a hormone, such as a polypeptide that is cleaved to form a shorter polypeptide hormone or a steroid that is converted to an active hormone by peripheral metabolism. Called also prehormone.

pro·hor·mone

(prō-hōr'mōn),
1. An intraglandular precursor of a hormone; for example, proinsulin. Compare: prehormone.
2. Obsolete term formerly used to designate a substance developed in serum that antagonizes a specific antihormone, and thus enhances the action of the corresponding hormone.

prohormone

/pro·hor·mone/ (-hor´mōn) a hormone preprotein; a biosynthetic, usually intraglandular, hormone precursor, such as proinsulin.

prohormone

(prō-hôr′mōn′)
n.
An inactive compound that is converted by enzymes into a biologically active hormone.

pro·hor·mone

(prō-hōr'mōn)
An intraglandular precursor of a hormone, e.g., proinsulin.
Compare: prehormone, bioregulator

pro·hor·mone

(prō-hōr'mōn)
Intraglandular precursor of a hormone; e.g., proinsulin.

prohormone

a precursor of a hormone, such as a polypeptide that is cleaved to form a shorter polypeptide hormone, or a steroid that is converted to an active hormone by metabolism.
References in periodicals archive ?
Acute hepatitis and personality change in a 31-year-old man taking prohormone supplement SUS500, Psychosomatics.
Studies in CKD patients have demonstrated that currently available over-the-counter and prescription vitamin D products cannot reliably raise blood vitamin D prohormone levels and effectively treat SHPT.
Copeptin, the C-terminal part of the vasopressin prohormone, is secreted stoichiometrically with arginine-vasopressin from the neurohypophysis.
PCT is the prohormone of calcitonin and is not normally present in the bloodstream of a healthy individual.
Because cardiac myocytes possess a biosynthetic apparatus, including enzymes for elaborate propeptide processing, cardiac prohormone maturation has proven to be much more complex than initially assumed.
An automated assay has also been launched for the N-terminal fragment of the homologous atrial natriuretic peptide (ANP) prohormone (1).
As a prohormone converted in the body to a hormone, vitamin D is critical for our health.
Human BNP is produced as a 108 amino acid prohormone, proBNP1-108 (proBNP108), which is converted to a biologically active peptide BNP1-32 (BNP32) and an inactive N-terminal (NT)-proBNP through proteolytic cleavage (4, 5).
LOS ANGELES -- Diagnostic Products Corporation (NYSE:DP) announced today the release outside the US of its assay for N-terminal prohormone brain natriuretic peptide (NT-proBNP).
Roche Diagnostics and Diagnostic Products Corporation (NYSE:DP) announced today that Diagnostic Products Corporation (DPC) has been granted a nonexclusive license under patent rights of Roche Diagnostics relating to the development, manufacture and marketing of immunoassays that detect a key marker of congestive heart failure (CHF), NT-proBNP (N-terminal prohormone brain natriuretic peptide).
Roche Diagnostics and Dade Behring announced today that Dade Behring has been granted a non-exclusive license under patent rights of Roche Diagnostics relating to the development, manufacture and marketing of immunoassays that detect a key marker of congestive heart failure (CHF), NT-proBNP (N-terminal prohormone brain natriuretic peptide).
Another potential convertase is the prohormone convertase 1 (PC1), which exists in atrial myocytes and maycleave proANP (28), but it is unknown whether PC1 circulates or whether it may process proBNP.