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progressive vaccinia

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progressive vaccinia
n.
A severe or even fatal form of vaccinia occurring as a complication of smallpox vaccination chiefly in persons with an immunologic deficiency or dyscrasia, characterized by progressive enlargement of the initial and secondary lesions.

vaccinia [vak-sin´e-ah]
the cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. See also cowpox and paravaccinia.
vaccinia gangreno´sa generalized vaccinia with failure to develop antibodies against the virus (due to agammaglobulinemia), with spreading necrosis at the site and metastasis of lesions throughout the body.
generalized vaccinia a condition of widespread vaccinial lesions resulting from sensitivity response to smallpox vaccination and delayed production of neutralizing antibodies.
progressive vaccinia vaccinia gangrenosa.


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Viewed in perspective, this would approximate the historic rate of vaccine-induced encephalitis and would be well in excess of the historic rate of progressive vaccinia.
In 1968, the rate of postvaccinial encephalitis and progressive vaccinia among first time vaccinees ranged from approximately 0.
Progressive vaccinia treated with ribavirin and vaccinia immune globulin.
 
 
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