progesterone receptor positive

progesterone receptor positive

Oncology A status of breast CA cells that have a receptor to which progesterone can attach; up to 80% of Pts with PR+ breast and endometrial CAs respond–ie, have a better prognosis–to hormonal manipulation
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Astellas) jointly announced the initiation of a Phase 2 clinical trial evaluating the safety and efficacy of enzalutamide in combination with exemestane in women with advanced breast cancer that is estrogen receptor positive (ER+) or progesterone receptor positive (PgR+) and human epidermal growth factor receptor 2 (HER2) normal.
Progesterone receptor positive breast cancer cells also have a higher uptake of glucose and demonstrate increased rates of glycolysis and lipogenesis, suggesting that progesterone facilitates the ability of PR + tumors to utilize any available fuel source for survival and growth.
In addition, there was an elevated risk of estrogen receptor positive and progesterone receptor positive tumors in Caucasian women related to a 500 gram per week increase in total red meat intake.
In 106 cases the tumors were progesterone receptor positive and the Recurrence Scores in these cases ranged from 1 to 39, with a mean Recurrence Score of 14.
2) In addition, male and female breast cancers differ in regards to expression of steroid hormone receptors (men are more likely to have estrogen and progesterone receptor positive tumors), (2) molecular markers (CerbB-2 and BCL-2 protooncogenes may have no prognostic significance in men, while in women it is associated with poor and favorable prognosis, respectively), (3) and genetics (as in women, men with BRCA-2 mutations are predisposed to develop breast cancer but BRCA-1 mutation does not seem to be a risk factor for breast cancer in men, although it has been described in affected men).
Current EPT use was significantly associated only with estrogen receptor positive (ER+) progesterone receptor positive (PR+) tumors (relative risk 1.
Consumption of soy isoflavones, found in soybeans and soy products, has increased in recent years and there are concerns about the effect of soy consumption on women with estrogen and progesterone receptor positive breast cancer as tumour growth is dependent on estrogen.
The Phase 2 study will evaluate whether the combination of MM-121 and exemestane is more effective than exemestane alone in postmenopausal women with locally advanced or metastatic estrogen receptor positive (ER+) and/or progesterone receptor positive (PR+), HER2-negative breast cancer.
double dagger]) Estrogen receptor positive, >14 fmol/mg of cytosolic protein; progesterone receptor positive, >10 fmol/mg of cytosolic protein.