Among the topics are biochemical genetic pathways that modulate aging in multiple species, how research on human progeroid
and antigeroid syndromes can contribute to the longevity dividend initiative, translating the science of aging into therapeutic interventions, inhibiting the mechanistic target of rapamycin (mTOR), the economic promise of delayed aging, and whether the rate of human aging has already been modified.
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid
features in laminopathy-based progeria.
syndromes are a group of disorders characterized by clinical features mimicking physiological ageing at an early age.
Here, we propose to use a unique series of knock-in, transgenic and NER progeroid
mice to decode the functional role of NER in mammals, thus paving the way for understanding how genome maintenance pathways are connected to developmental defects and disease mechanisms in vivo.
Some Lmna mutations cause progeroid
syndromes, which are characterized by features of accelerated aging (Eriksson et al.
INTRODUCTION: Werner's syndrome is a progeroid
Buyume geriligi veya boy kisaligi olan cocuklarda metabolik hastaliklar, Cockayne sendromu, serebro-okulo-fasiyo-skeletal sendrom (COFS), iskelet displazileri, progeroid
The normal hair and eyes help to distinguish the condition from other progeroid
Molecular aging in progeroid
syndromes: Hutchison-Glifordprogeria syndrome as a model.
mice age more quickly and have a lifespan of 8 months.
Citation: "Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid
phenotypes in Polg mutator mice;" Kati Ahlqvist, Anu Suomalainen et al.
Topics covered include clinical features of Cockayne and related syndromes, the molecular basis and molecular diagnosis of CS transcription-coupled repair, CS Group B protein and chromatin structure, cell signaling, cell cycle defects and apoptosis in CS, and overlap with xeroderma pigmentosum and other progeroid