Researchers found that VB6 provides a specific up-regulation of profilaggrin
mRNA/protein in keratinocytes.
Bu hucrelerdeki involucrin, profilaggrin
ve loricrin ekspresyonunda azalma ve keratohiyalin granullerinde kayip gozlenmistir.
4) Research has demonstrated that AFA do not target filaggrin or profilaggrin
in patients with RA, but instead are directed towards other citrullinated proteins.
is a product of the keratohyalin granules.
, which is present in the keratohyalin granules of human buccal mucosa cells, is proteolytically cleaved into several filaggrin subunits during cell differentiation.