profilaggrin

profilaggrin

a structural protein synthesized by cells of the stratum granulosum and a precursor of filaggrin.
References in periodicals archive ?
An association between Profilaggrin and ichthyosis vulgaris is also possible.
It en-codes a polyprotein precursor known as profilaggrin (400-kDa) composed of numerous tandem filaggrin repeats.
Researchers found that VB6 provides a specific up-regulation of profilaggrin mRNA/protein in keratinocytes.
Bu hucrelerdeki involucrin, profilaggrin ve loricrin ekspresyonunda azalma ve keratohiyalin granullerinde kayip gozlenmistir.
4) Research has demonstrated that AFA do not target filaggrin or profilaggrin in patients with RA, but instead are directed towards other citrullinated proteins.
Profilaggrin, which is present in the keratohyalin granules of human buccal mucosa cells, is proteolytically cleaved into several filaggrin subunits during cell differentiation.
The main risk factors for AD are a family history, present in approximately (70) % of patients, and loss-of-function mutations in the FLG gene, which encodes profilaggrin.
The main risk factors for AD are a family history, present in approximately 70% of patients, and loss-of-function mutations in the FLG gene, which encodes profilaggrin.
Filaggrin gene (FLG) mutations in patients with atopic dermatitis result in inadequate production of profilaggrin and filaggrin and in reduced corneocyte osmolytes.
Filaggrin is named after 'filament aggregating protein' and is produced from a precursor, profilaggrin, by proteolysis.
Filaggrin gene (FLG) mutation in patients with atopic dermatitis result in inadequate production of profilaggrin and filaggrin and in reduced corneocyte osmolytes.