1) CAP'S PT program utilizes samples identical to patient samples and not only validates individual laboratories but utilizes peer comparison to generate more accurate ranges for proficiency samples
In proficiency samples
, we statistically determined the Luminex cutoff values that can predict a positive XM to be more than 2 SDs from the mean of samples associated with a negative XM.
In both cases 1) the hospital laboratories received proficiency samples
containing the Sterne strain; 2) the Sterne strain was isolated from the patient specimens only after broth enrichment of wound specimens, a practice generally not considered appropriate for nonsterile sites such as wounds; and 3) both patient specimens and proficiency samples
were in the same laboratory area at the same time, including, in case 2, in the same biosafety cabinet.
We thought this difference could be attributable to either inappropriate freeze-thawing of the CAP proficiency samples
by a large number of reporting laboratories, a procedure that is expressively proscribed by CAP, or that the Immulite platform yields lower plasma ACTH results than the Scantibodies IRMA.
Proficiency testing is the ongoing process in which a series of proficiency samples
, the characteristics of which are not known to the participants, are sent to laboratories on a regular basis.
Cement and Concrete Reference Laboratory Proficiency Sample
Program: Final Report Portland Cement Proficiency Samples
Number 133 and 134, Cement and Concrete Reference Laboratory, Gaithersburg, MD, September 1999.
Commenting on the recent reports in the general press regarding the recommendation by the World Health Organization (WHO) that testing laboratories destroy proficiency samples
containing influenza A virus, the Company noted it produces such samples for the College of American Pathologists (CAP).
We also prepare and provide microbiology proficiency samples
to various clinical proficiency providers in the United States.
Extraction of whole-blood calibrators, controls, proficiency samples
, and human specimens was performed according to a recently published protocol (7).
This technology enables the shipment of inactivated influenza proficiency samples
to more than 4,000 diagnostic testing facilities to assess their ability to accurately screen and report influenza infections.
Those proficiency samples
that were found to have associated with them an increased imprecision for measurement of estradiol contained unconjugated estriol at concentrations >3 [micro]g/L.
These criteria, coupled with a good quality control program including XB (range of means), external proficiency samples
, and other sample comparisons can help assure quality operations in a hematology laboratory.