proenzyme


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Related to proenzyme: proteolytic, apoenzyme, coenzyme, zymogen, Allosteric enzyme

proenzyme

 [pro-en´zīm]
zymogen; an inactive precursor of an enzyme.

pro·en·zyme

(prō-en'zīm),
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active; for example, pepsinogen, trypsinogen, profibrolysin.
Synonym(s): zymogen

proenzyme

/pro·en·zyme/ (pro-en´zīm) an inactive precursor that can be converted to active enzyme.

proenzyme

(prō-ĕn′zīm′)
n.
The inactive or nearly inactive precursor of an enzyme, converted into an active enzyme by proteolysis. Also called zymogen.

pro·en·zyme

(prō-en'zīm)
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active, e.g., pepsinogen, trypsinogen, profibrinolysin.
Synonym(s): zymogen.

proenzyme

A protein that can give rise to an enzyme.

proenzyme

zymogen; an inactive precursor of an enzyme.
References in periodicals archive ?
As a result of positive early indications of the anti-cancer effects of our technology, we intend to submit our proenzyme treatment to the rigorous, formal non-clinical and clinical development and trial processes required to obtain the regulatory approval necessary to commercialize it and any product(s) derived and/or to be derived therefrom.
Proenzyme PSA for the early detection of prostate cancer in the 2.
Furthermore, we detected 2 forms of MMP-7 in CAL 54 cell line supernatant: pro-MMP-7 and mature MMP-7, which is the result ofactivation of the proenzyme; however, our results demonstrated an IgG immunoreactivity only against the proenzyme.
In our previous assays based on the same principle, both activation of the proenzyme and detection of the activity of the activated proenzyme with a chromogenic peptide substrate were performed simultaneously, and the relationship between color formation and incubation time was parabolic.
hK7 is predicted to be translated as a pre-proenzyme that is processed and secreted as a proenzyme into the extracellular space, similarly to other extracellular proteases (6).
Analysis of an apo(a) cDNA from a human liver library in 1987 revealed that apo(a) bears striking homology with the fibrinolytic proenzyme plasminogen and is a member of the plasminogen gene superfamily (7).
This includes one form of PSA that has been identified as the proenzyme, or precursor form of PSA (pPSA), which is associated with cancer (11-14).
To activate the inactive recombinant CLN2 proenzyme secreted by the cells, 10-[micro]L samples (undiluted or diluted two-, four-, or eightfold in phosphate-buffered saline) were mixed with 20 [micro]L of 150 mmol/L NaCl-1 g/L Triton X-100-50 mmol/L formic acid/sodium formate, pH 3.
The Inactive enzymes, or proenzymes, contained in pancreatic zymogen granules are listed below along with the specific substances theey digest when activated.