proenzyme


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proenzyme

 [pro-en´zīm]
zymogen; an inactive precursor of an enzyme.

pro·en·zyme

(prō-en'zīm),
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active; for example, pepsinogen, trypsinogen, profibrolysin.
Synonym(s): zymogen

proenzyme

/pro·en·zyme/ (pro-en´zīm) an inactive precursor that can be converted to active enzyme.

proenzyme

(prō-ĕn′zīm′)
n.
The inactive or nearly inactive precursor of an enzyme, converted into an active enzyme by proteolysis. Also called zymogen.

pro·en·zyme

(prō-en'zīm)
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active, e.g., pepsinogen, trypsinogen, profibrinolysin.
Synonym(s): zymogen.

proenzyme

A protein that can give rise to an enzyme.

proenzyme

zymogen; an inactive precursor of an enzyme.
References in periodicals archive ?
2002) Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin.
Proenzyme PSA for the early detection of prostate cancer in the 2.
The proenzymes from dogs and rabbits require high concentrations of streptokinase for activation.
We suggest that these hemocytes are stimulated to release prophenoloxidase immediately before or after ecdysis, and the proenzyme moves across the epidermis into the layers of the newly secreted exoskeleton.
Proenzyme prostate specific antigen (pPSA) does a better job of detecting prostate cancer and helping prevent unnecessary biopsies than free PSA (fPSA) does, according to the results of a preliminary study reported in the February issue of Urology.
Becker had recently discovered that the first component (C1), subsequently identified as subunit C1q, was a protease proenzyme that was activated by contact with antigen-antibody complexes.
Caspase-3 is synthesized as inactive proenzyme, where upon cleavage at Asp175/Ser176, is converted to the active enzyme.
Activation of the proenzyme involves proteolytic removal of the N-terminal proregion containing the cysteine switch motif conserved in matrix metalloproteinases (18).
Evidence that cathepsin L-like proteinase is stored as a latent, acid-activable proenzyme.
It is a cytosolic protein as an inactive 32-kDa proenzyme and is activated by proteolytic cleavage into the 20 kDa (p20) and 11 kDa (p11) active subunits.
The protease to be measured converts a proenzyme into an active enzyme (detection enzyme), and the activity of the latter is detected (Fig.
Urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are serine proteases that catalyse the conversion of a proenzyme, plasminogen, to active plasmin and play important roles in thrombolysis (Blasi et al.