prodrug


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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

/pro·drug/ (-drug) a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

[prō′drug]
an inactive or partially active drug that is metabolically changed in the body to an active drug.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.

prodrug

drug modified by biotransformation (i.e. metabolic processes) to achieve desired pharmacological action

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
References in periodicals archive ?
It develops new molecular entities (NMEs) using incremental innovation and prodrug technology targeted to provide better pharmacokinetic, pharmacodynamics, physicochemical properties, and to enable the development of known agents for both existing and new indications.
Biopharmaceutical company Biohaven Pharmaceutical Holding Company Ltd (NYSE:BHVN) reported on Wednesday the receipt of a Notice of Allowance from the US Patent and Trademark Office (USPTO) covering certain prodrugs of the glutamate modulating agent riluzole.
mefenamic acid, after converting it to macromolecular prodrug as HPC- mefenamic acid conjugates.
The tumor cell then folds its membrane in to enclose the receptor and prodrug in a bubble and bring them into the cell (receptor-mediated endocytosis).
Cascade Prodrug doesn't plan to manufacture or sell compounds under its own label.
The prodrug strategy produced a greater than 5,000-fold increase in water solubility compared to SB-3CT.
In line with this corporate vision, the company will accelerate the development of ravuconazole prodrug.
A prodrug is a drug that is administered in an inactive - or significantly less active - form.
The gabapentin prodrug XP13512 has several potential advantages over standard gabapentin for treating RLS: The agent has linear pharmacokinetics, doesn't reach a saturation point, and is formulated for sustained release.
The claims awarded in this patent reflect the highly innovative nature of the targeted prodrug technology embodied in Semafore's lead compound," said Ronald Henriksen, chief executive office of Semafore.
The enzyme only attaches to cancerous cells, so that when the prodrug is given it passes harmlessly through healthy tissue, targeting only a tumour.
Under terms of the agreement, Merck will contribute drug candidates to the collaboration and Metabasis will apply its liver targeting, HepDirect prodrug technology with the objective of identifying novel drugs for the treatment of the disease.