prodrug


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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

/pro·drug/ (-drug) a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

[prō′drug]
an inactive or partially active drug that is metabolically changed in the body to an active drug.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.

prodrug

drug modified by biotransformation (i.e. metabolic processes) to achieve desired pharmacological action

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
References in periodicals archive ?
ContraVir's lead clinical drug, FV-100, is an orally available nucleoside analogue prodrug that is being developed for the treatment of herpes zoster, or shingles, which is currently in Phase 3 clinical development.
Because of this unique combination of properties my new light-activatable ruthenium prodrugs will ultimately lead to selective anticancer treatment showing low side effects for cancer patients.
The tumor cell then folds its membrane in to enclose the receptor and prodrug in a bubble and bring them into the cell (receptor-mediated endocytosis).
Cascade Prodrug doesn't plan to manufacture or sell compounds under its own label.
The prodrug strategy produced a greater than 5,000-fold increase in water solubility compared to SB-3CT.
In line with this corporate vision, the company will accelerate the development of ravuconazole prodrug.
A prodrug is a drug that is administered in an inactive - or significantly less active - form.
The claims awarded in this patent reflect the highly innovative nature of the targeted prodrug technology embodied in Semafore's lead compound," said Ronald Henriksen, chief executive office of Semafore.
The therapy, known as Adept, uses the ability of an enzyme to turn other- wise harmless mole- cules, or prodrugs, into cell-killing drugs.
Metabasis says the HepDirect technology is a prodrug technology that specifically targets production of the biologically active form of certain drugs to the liver and preclinical studies have show that the use of the technology may result in higher active drug concentrations in the liver and decreased exposure to non-liver tissue.
Medarex received its rights to Super-Leu-Dox (CPI-0004) through the acquisition of Corixa Corporation's Tumor Activated Prodrug (TAP) program.
From a pharmacodynamic perspective, the contributions of prodrug, active drug, and drug metabolites to the overall pharmacological activity need to be known.