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procollagen

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procollagen /pro·col·la·gen/ (-kol´ah-jen) the precursor molecule of collagen, synthesized in the fibroblast, osteoblast, etc., and cleaved to form collagen extracellularly.
pro·col·la·gen (pr-kl-jn)
n.
The soluble precursor of collagen possibly formed by fibroblasts in the process of collagen synthesis.
procollagen
the precursor of collagen, synthesized in osteoblasts and fibroblasts and subsequently converted to form collagen by procollagen peptidase.
procollagen N-peptidase
one of the enzymes involved in the conversion of procollagen to collagen. There is inadequate activity of this enzyme in osteogenesis imperfecta, dermatosparaxis.
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Tissue stretch decreases soluble TCF-betal and type-1 procollagen in mouse subcutaneous connective tissue: evidence from ex vivo and in vivo models.
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In conclusion, the findings of this study collectively provide compelling evidence that differentiated keratinocytes release collagenase-stimulatory 14-3-3s protein for dermal fibroblasts and that this may in turn control degradation of the major dermal ECM components such as type I and type III procollagen.
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Basement membrane proteins and type III procollagen in murine schistosomiasis.
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