procollagen


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Related to procollagen: tropocollagen

pro·col·la·gen

(prō-kol'ă-jen),
Soluble precursor of tropocollagen formed by fibroblasts and other cells in the process of collagen synthesis; unstable type III procollagen is associated with Ehlers-Danlos syndrome type IV.

procollagen

/pro·col·la·gen/ (-kol´ah-jen) the precursor molecule of collagen, synthesized in the fibroblast, osteoblast, etc., and cleaved to form collagen extracellularly.

pro·col·la·gen

(prō-kol'ă-jen)
Soluble precursor of collagen formed by fibroblasts and other cells in the process of collagen synthesis.

procollagen

the precursor of collagen, synthesized in osteoblasts and fibroblasts and subsequently converted to form collagen by procollagen peptidase.

procollagen N-peptidase
one of the enzymes involved in the conversion of procollagen to collagen. There is inadequate activity of this enzyme in osteogenesis imperfecta, dermatosparaxis.
References in periodicals archive ?
Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment [published correction appears in Am J Respir Crit Care Med.
The primers for Mfn2 , the reference gene [sz] -actin, and procollagen 1A1/1A2/3A1 were synthesized by Shanghai Sangon Biotech (China).
We measured the concentrations of LDH, GSH, MMP-1, MMP-3, IL-6, procollagen type I and TGF-[beta]1 in the medium with commercially available kits according to the manufacturer's instructions.
To examine whether MHY498 has protective effect on a collagen precursor in fibroblasts after UVB exposure, we measured intracellular type 1 procollagen (a major collagen precursor in skin) concentration in human dermal fibroblasts cultured primarily from human fetal skin [23] using an ELISA kit.
Effect of low-power laser irradiation on procollagen synthesis in human fibroblasts.
Therefore, National Bone Health Alliance (NBHA) is conducting a project to standardize bone turnover marker sample collection procedures in the USA, establish a USA reference range for one bone formation (serum procollagen type I N propeptide, P1NP) and one bone resorption (serum C-terminal telopeptide of type I collagen, s-CTX) marker, and standardize bone turnover marker assays used in clinical laboratories and stress the importance of harmonization for future research [13].
Aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), total bilirubin (TBIL) of liver function indexes and III procollagen (PC III), laminin (LN), hyaluronidase (HA) of liver fibrosis indexes between the two groups were compared.
They encode the two chains pro [alpha]1(I) and pro [alpha]2(I), respectively, of Type I procollagen.
The bone formation marker, serum type I procollagen, rose inexplicably with placebo, but this increase was surpassed by a significant gain of 31.
Effect of low power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts.
Skin samples taken from groups before and after trial showed an increase in levels of procollagen, a molecule which gives skin its structure and loss of which leads to skin ageing and lack of elasticity.
Recent evidence indicates that IR and heat may induce premature skin aging, just like UV radiation including: (a) IR exposure of human skin stimulates the expression of MMP-1 and decreases type I procollagen expression in vivo.