procoagulant


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procoagulant

 [pro″co-ag´u-lant]
1. tending to promote coagulation.
2. a precursor of a natural substance necessary to coagulation of the blood.

procoagulant

/pro·co·ag·u·lant/ (-ko-ag´ūl-int)
1. tending to promote coagulation.
2. a precursor of a natural substance necessary to coagulation of the blood.

procoagulant

(prō′kō-ăg′yə-lənt)
n.
1. The precursor of any of various blood factors necessary for coagulation.
2. An agent that promotes the coagulation of blood.

procoagulant

[-kō·ag′yələnt]
an inactive coagulation protein that becomes activated during the coagulation process to form a serine protease or cofactor and produce a fibrin clot. Prothrombin is an example.

procoagulant

adjective Favoring coagulation; referring to activation of coagulation factors noun Any agent–eg, thrombin, factor Xa, which clots blood

procoagulant

1. tending to promote coagulation.
2. a precursor of a natural substance necessary to coagulation of the blood.
References in periodicals archive ?
Fresh frozen plasma must be given 10-20 ml/kg every 8-12 h in order to replace the procoagulant and anticoagulant proteins consumed in the disease process.
Their use is based on the rationale that congenital deficiencies in any of the procoagulant factors translate into defective thrombin generation and, hence, into defective fibrinogen-to fibrin conversion and prolonged PT or APTT.
Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.
Platelets provide a procoagulant surface for amplification of cancer-related coagulation.
Ozsoylu has already specified, due to the coagulation being dependant on the dynamic balance between procoagulant and fibrinolytic activity, fibrinolytic system could have been evaluated as well.
In addition to all these factors, increase in production of tumor necrosis factor (15) and decrease in production of glycosaminoglucan in the intestines may also have procoagulant effect (16).
In addition, elevated biomarkers of inflammation (increased IL-6, CRP) and procoagulant effects (in vivo platelet activation, elevated D-dimer) developed in asymptomatic AMAA runners during races, indicates a transient susceptibility to atherothrombosis.
In this study, we examined if both compounds affected the expression of the procoagulant tissue factor (TF) induced by lipopolysaccharide (LPS) on human monocyte.
Cushing's disease is known to carry risks for arterial and venous thrombosis, given the typical accompanying increases in procoagulant factors and reduced fibrinolytic activity (12).
There have been promising reports of the use of recombinant factor VIIa (rVIIa) for treating hemorrhage in patients with AFE in recent years, but a recent review of case reports of AFE from 2003 to 2009 suggests that the procoagulant may actually worsen outcomes (Anesthesiology 2011;115:1201-8).
Use of procoagulant reversal agents such as prothrombin complex concentrate (PCC), activated prothrombin complex concentrate (APCC), or recombinant factor VIIa (rFVIIa) may be considered, but has not been evaluated in clinical trials.