Disorders of platelet procoagulant
activity (Scott syndrome)
These MVs and remnant erythrocytes expressed phosphatidylserine (PS), an important mediator of procoagulant
19) The first hypothesis suggests that CMV leads to a thrombotic micro-angiopathy by changing the nature of the endothelium from a anticoagulant to a procoagulant
Hypertriglyceridemia may present a procoagulant
state since PAI-1 is increased in the presence of hypertriglyceridemia (Tholstrup et al.
Thus, lifelong increased concentrations of complement C3 may biologically be considered a procoagulant
state, as also suggested by the present results.
Increased levels of procoagulants
and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis.
Monocyte-derived MVs are like endothelial-derived and erythrocyte-derived MVs significant sources of procoagulant
activity due to their expression of tissue factor [40, 41], as well as of phosphatidylserine, a cofactor in the coagulation cascade .
Moreover, C5a can induce heparansulphate release from endothelial cell membranes so promoting a procoagulant
activity and the membrane attack complex might mediate von Willebrand secretion and tissue factor expression.
Elevated levels of PGM may also inhibit the activated protein C (APC)- mediated inactivation of factor V Leiden leading to a procoagulant
Conclusions: CAD patients had a procoagulant
state and presented with higher levels of hsCRP compared to the healthy individuals.
Visseren FL, Bouwman JJ, Bouter KP, Diepersloot RJ, de Groot PH, Erkelens DW: Procoagulant
activity of endothelial cells after infection with respiratory viruses.
They may comprise triggering factors for the initiation and/ or acceleration of an ongoing inflammatory process by increased expression of adhesion molecules and inflammatory cytokines, procoagulant
effects, increased receptor expression and activity, enhanced uptake of cholesterol and of modified low-density lipoprotein, increased smooth muscle cell migration and proliferation, anti-apoptotic effects, and autoimmune response to infection (4).