Certain agents have been identified as particularly gonadotoxic to the testes, including the alkalating agents procarbazine
, cisplatinum and vinblastine.
In the acute ovarian failure of childhood cancer survivor study  that included 3309 childhood cancer survivors, exposure to more than 1000 cGy ovarian radiation, age and treatment with cyclophosphamide or procarbazine
were found as independent risk factors for development of POF in a multivariable logistic regression model.
An increase in the anticoagulant effect of warfarin was observed in patients on carboplatin, cyclophosphamide, doxorubicin, etoposide, 5-fluorouracil, gemcitabine, ifosfamide, methotrexate, procarbazine
, tamoxifen, and vincristine.
Food and Drug Administration (FDA) in March 2005 for refractory AA in patients who have experienced disease progression on a drug regimen containing nitrosurea and procarbazine
, and for the treatment of newly diagnosed GBM in combination with radiotherapy and then as maintenance therapy.
Suspect Drugs Chemotherapy Agents Associated With Neurotoxicity Combination of methotrexate*, cyclophosphamide, and fluorouracil* Vinca alkaloids Cytarabine Platinum analogues Ifosfamide Taxol Taxotere Fludarabine Suramin Agents Associated With Occasional Reports of Cognitive or Motor Impairment L-asparagine Busulfan Hexamethylmelamine Procarbazine
Thiotepa *Also associated with cognitive impairment individually.
Bioassay of Procarbazine
for Possible Carcinogenicity (CAS No.
The agents must be either lipophilic, such as procarbazine
, or given in high enough doses to penetrate the CNS (e.
The treatment for Hodgkin lymphoma is dominated by the combination of generic drugs like doxorubicin, bleomycin, vinblastine, dacarbazine, mechlorethamine, etoposide, vincristine, prednisone, cyclophosphamide, procarbazine
, chlorambucil, methylprednisolone, cytarabine, cisplatin and dexamethasone.
And its implementing acts (excluding drugs on the import target set out in the packages - Package 52 Lomustine, 66 procarbazine
package, Package 70 Thalidomidum).
This product is the generic equivalent to Temodar (temozolomide), indicated for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment and refractory anaplastic astrocytoma patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine
Treatment of patients with HL was based on adriamycin, bleomycin, vinblastine, and dacarbazine or on bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine
, and prednisone regimens.
The most commonly used chemotherapy drugs have been alkylating agents, such as procarbazine
(Matulane), temozolomide (Temodar), and the nitrosureas, carmustine (BCNU) and lomustine (CCNU).