proband


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Related to proband: propositus, consultand

pro·band

(prō'band),
In human genetics, the patient or member of the family that brings a family under study.
Synonym(s): index case
[L. probo, to test, prove]

proband

/pro·band/ (pro´band) an affected person ascertained independently of relatives in a genetic study.

proband

(prō′bănd′, prō-bănd′)

proband

proband

Epidemiology A Pt who triggers study of other members of the family to identify the possible genetic factors involved in a given disease, condition, or characteristic. Cf Index case.

pro·band

(prō'band)
human genetics The patient or member of the family that brings a family under study.
[L. probo, to test, prove]

proband

The presenting patient of a group with an identical or similar disorder, especially the member of a family first found to have an inheritable disorder. Also known as propositus.

proband

an individual considered as the starting point for the study of a family for the inheritance of a particular condition.

proband

propositus.
References in periodicals archive ?
We identified the same mutation in one allele of the TR[beta] gene in the proband (subject III-3 in Figure 1), his two brothers (III-5 and III-6) and father (II-8).
For the same reason, the DZ co-twins of probands selected for a phenotype in one tail of a distribution should regress halfway to the population mean.
Of the 200 probands (100 children and 100 adults) with asthma, complete pedigree was available for 140 probands (62 children and 78 adults) for evaluating the inheritance patterns.
At age 48, the proband in this report developed infraclavicular lymphadenopathy.
Some studies show that female relatives of the fibromyalgia probands display higher rates of psychiatric disorders than do male relatives," said Dr.
In general, studies using alcoholic probands found that relatives were not at increased risk for depression unless the proband also had depression.
A single ancestral chart for one proband could therefore contain at least 511 individuals, corresponding to the eight generations ancestral to the proband.
The proband and his parents were screened via direct sequencing of the region including 5' UTR (-101 position) of the [beta]-globin to 3' UTR (Poly-A signal) in the [beta]-globin gene.
In 1932, pediatrician Robert Pottenger, MD, did a very important experiment in cats, documenting the dramatic effects of nutrition not only to the proband generation but to successive generations as well.
The current study is also the first to consider "the full spectrum of ACS without age restrictions on the proband or parent at time of vascular event," they stated.