The team will also carefully engineer novel gene-therapy approaches to avoid the development of regional inhomogeneity in protein expression that may facilitate proarrhythmic
Rapid responses and mechanism of action for low-dose bisphenol S on ex vivo rat hearts and isolated myocytes: evidence of female-specific proarrhythmic
Because of the proarrhythmic
effects of SOTYLIZE including a 1.
Groups at increased risk for torsades de pointes are those with known prolongation of the QT interval, history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failure, as well as those on drugs known to prolong the QT interval, those with ongoing proarrhythmic
conditions, those with clinically significant bradycardia, and patients treated with class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmic drugs.
A chart review of these seven cases showed that three of these patients died of complications following carotid endarterectomy surgery, and two died of cardiac arrests in the context of overdoses with proarrhythmic
Jonsson, Qing-Dong Wang, Bruno Becker: Impedance-Based Detection of Beating Rhythm and Proarrhythmic
Effects of Compounds on Stem Cell-Derived Cardiomyocytes.
A comprehensive analysis of QT interval assessments including the QTc interval was performed in AMP-516 per ICH E14 Guidance: Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic
Potential for Non-Anti-arrhythmic Drugs (October 2005, ICH).
The decline in mortality due to arrhythmia could be explained by the reduction in use of proarrhythmic
drugs and more widespread use of beta blockers and defibrillators, the researchers say.
However, the problem with all class III antiarrhythmic agents is prolongation of cardiac repolarization resulting in proarrhythmic
School of Pharmacy, Turner and Durham (who also works in biostatistics and data management at a pharmaceutical company) detail a strategy for screening drugs for adverse cardiac effects that integrates proarrhythmic
, generalized, and behavioral aspects into one comprehensive volume for researchers in drug discovery and development, as well as health professionals and students.
The AHA recommends the QT interval should be measured in patients who have received any antiarrhythmic drug known to cause TdP, overdosed from a potentially proarrhythmic
agent, developed new-onset bradyarrhythmias, severe hypokalemia or hypomagnesemia, require antipsychotics, and experienced an acute neurological event (Drew, 2005).
The use of antiarrhythmic drugs is accompanied by intrinsic hazards, such as proarrhythmic
and toxic effects as well as severe bradycardia immediately after the induction of anesthesia .