proarrhythmia

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proarrhythmia

/pro·ar·rhyth·mia/ (pro″ah-rith´me-ah) cardiac arrhythmia that is either drug-induced or drug-aggravated.proarryth´mic

proarrhythmia

Cardiology A drug-related arrhythmia, seen in 4–6% of Pts treated for V tach or V fib, especially in Pts treated with digitalis & diuretics, ↓ left ventricular function, longer pretreatment Q-T intervals Pathogenesis Altered reentry substrate and early after depolarization. See Arrhythmia.

proarrhythmia

(prō-ă-rĭth′mē-ă)
An arrhythmia that is stimulated, provoked, or worsened by drug therapy.
proarrhythmic, adjective
References in periodicals archive ?
The team will also carefully engineer novel gene-therapy approaches to avoid the development of regional inhomogeneity in protein expression that may facilitate proarrhythmic events.
Rapid responses and mechanism of action for low-dose bisphenol S on ex vivo rat hearts and isolated myocytes: evidence of female-specific proarrhythmic effects.
Because of the proarrhythmic effects of SOTYLIZE including a 1.
Groups at increased risk for torsades de pointes are those with known prolongation of the QT interval, history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failure, as well as those on drugs known to prolong the QT interval, those with ongoing proarrhythmic conditions, those with clinically significant bradycardia, and patients treated with class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmic drugs.
A chart review of these seven cases showed that three of these patients died of complications following carotid endarterectomy surgery, and two died of cardiac arrests in the context of overdoses with proarrhythmic medication.
Jonsson, Qing-Dong Wang, Bruno Becker: Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-Derived Cardiomyocytes.
A comprehensive analysis of QT interval assessments including the QTc interval was performed in AMP-516 per ICH E14 Guidance: Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Anti-arrhythmic Drugs (October 2005, ICH).
The decline in mortality due to arrhythmia could be explained by the reduction in use of proarrhythmic drugs and more widespread use of beta blockers and defibrillators, the researchers say.
However, the problem with all class III antiarrhythmic agents is prolongation of cardiac repolarization resulting in proarrhythmic effects (32).
School of Pharmacy, Turner and Durham (who also works in biostatistics and data management at a pharmaceutical company) detail a strategy for screening drugs for adverse cardiac effects that integrates proarrhythmic, generalized, and behavioral aspects into one comprehensive volume for researchers in drug discovery and development, as well as health professionals and students.
The AHA recommends the QT interval should be measured in patients who have received any antiarrhythmic drug known to cause TdP, overdosed from a potentially proarrhythmic agent, developed new-onset bradyarrhythmias, severe hypokalemia or hypomagnesemia, require antipsychotics, and experienced an acute neurological event (Drew, 2005).
The use of antiarrhythmic drugs is accompanied by intrinsic hazards, such as proarrhythmic and toxic effects as well as severe bradycardia immediately after the induction of anesthesia [5].