proarrhythmia


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proarrhythmia

/pro·ar·rhyth·mia/ (pro″ah-rith´me-ah) cardiac arrhythmia that is either drug-induced or drug-aggravated.proarryth´mic

proarrhythmia

Cardiology A drug-related arrhythmia, seen in 4–6% of Pts treated for V tach or V fib, especially in Pts treated with digitalis & diuretics, ↓ left ventricular function, longer pretreatment Q-T intervals Pathogenesis Altered reentry substrate and early after depolarization. See Arrhythmia.

proarrhythmia

(prō-ă-rĭth′mē-ă)
An arrhythmia that is stimulated, provoked, or worsened by drug therapy.
proarrhythmic, adjective
References in periodicals archive ?
Older agents have treatment limitations, including contraindications which prevent use in structural heart disease for some, proarrhythmia or slow onset of action which may explain the need for longer hospital stays in others.
Beta-blockers can also be implicated if abruptly withdrawn preoperatively, leading to a postoperative sinus tachycardia and hypertension; postoperative use such as in coarctation repair may be associated with with bradycardia or AV block; or proarrhythmia.
Dronedarone exhibited a favorable safety profile, most importantly with regard to its reassuringly low proarrhythmia potential.
Drug-induced proarrhythmia and the use of QTc prolonging agents: Clues for clinicians.
Proarrhythmia is observed in patients treated with drugs that block the hERG channel, including quinidine, dofetilide, antihistamines, and antibiotics (Bednar et al.
Proarrhythmia with class III antiarrhythmic drugs: types, risks, and management.
The Survival with Oral D-Sotalol Trial (16) tested the effect of D-sotalol, a sotalol isomer without a [beta]-blocking effect, and also demonstrated increased proarrhythmia by the active drug.
These safety issues include risk of drug induced proarrhythmia and other cardiac liabilities.
Clinical experience in an acute coronary syndrome population did not show an increased risk of proarrhythmia or sudden death.
Therefore, the unmonitored use of quinolones is most likely safe and the risk of proarrhythmia is low in patients who do not have other factors increasing their risk for QT interval prolongation.