primase


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pri·mase

(prī'māz),
A polymerase that acts on a template DNA strand to produce RNA, resulting in the formation of an RNA primer needed in RNA replication.
Synonym(s): dnaG
[primer + -ase]

primase

an ENZYME that synthesizes RNA PRIMERS during DNA replication in bacteria and certain single-stranded DNA phages. The RNA primers can then be extended by DNA POLYMERASE (see DNA (b) REPLICATION).

primase

a specialized RNA polymerase that synthesizes short stretches of RNA used as primers.
References in periodicals archive ?
Helicase primase inhibitors target the virus helicase-primase complex, which is involved in DNA replication.
Primase Gene-specific primers: because we do not want the entire DNA strand replicated, we add premade primers specific to the single exon in our gene sequence rather than adding the primase enzyme.
Myricetin inhibits Escherichia coli DnaB helicase but not primase.
Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum.
The findings, published in the March 31 issue of Science, provide an atomic-resolution image of the DnaG primase protein, which performs the essential step of producing RNA primers that are required for initiating DNA replication of the bacterial chromosome.
In today's report, researchers described the active site of the core catalytic domain of the DnaG primase protein as determined by x-ray crystallography.