The key point, she said, was that the drug managed to nearly eliminate metastases without shrinking the primary tumor
However, considering that a statistically substantiated analysis in only 77 patients was not feasible, we extended the ERCC1 analysis with primary tumor
tissues from a further 111 independent ovarian cancer patients from whom no blood samples for [ERCC1.
16) The mean primary tumor
size for the entire group was 3.
In effect, the primary tumor
arts like a filling station, giving these tumor cells more energy to go out and metastasize in different sites.
Carey, in a conference-closing summary of the past year's progress in advanced breast cancer, noted that the 2010 ASCO meeting included three studies comprising roughly 520 patients, all showing "small but real changes" in hormone receptor and HER2 status between the primary tumor
and metastatic disease.
Some consider the R classification to apply only to the primary tumor
and its local or regional extent.
The investigators found no significant differences in 48 genes between brain metastases and the primary tumor
sites, except for PIK3CA in breast cancer, which was mutated less frequently in brain metastases than in the primary breast samples (10% vs.
With today s approval, Lymphoseek can now be used to guide testing of lymph nodes closest to a primary tumor
for cancer, called a sentinel lymph node biopsy, in patients with cancer of the head and neck.
However, if researchers can identify the biochemical pathway that controls Par-4, or molecules that can modulate Par-4 activity directly, they may be able to increase the efficacy of neoadjuvant therapy of primary tumors
as well as treat recurrent breast cancers more effectively, Alvarez said.
pT4: Primary tumor
invades bone, muscle, fascia, or cartilage
None of the changes was related to treatment of the primary tumor
Among the patients with a second primary tumor
, 59% presented within 1 year of their first tumor.