primary syphilis


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Related to primary syphilis: chlamydia, HPV

pri·mar·y syph·i·lis

the first stage of syphilis See: syphilis.

primary syphilis

n.
The first stage of syphilis, characterized by formation of a painless chancre at the point of infection and hardening and swelling of adjacent lymph nodes.

primary syphilis

See syphilis.

primary syphilis

Infectious disease A common STD caused by a spirochete, Treponema pallidum transmitted through sexual contact–especially since toilet seats have been definitively excluded Sobering factoid Risk of contracting syphilis from an infected sex partner after one episode of unprotected sex is 30% Epidemiology US, 100,000 new cases/yr–third most commonly reported STD, gonorrhea is first, herpes is numero dos; it is more common in urban areas, in the south, ages 15 to 25, and may be asymptomatic Stages Primary, secondary, latent–hidden, benign late, tertiary Clinical Usually presents as a small painless ulcer–ie, a chancre, 10 days to 6 wks post exposure which, if on the penis, is easily diagnosed, but not on the labia, cervix, anal area, or mouth Appearance Shallow, sharply defined borders, slightly raised edges, base of the ulcer is clean and free of debris, it is typically painless and indurated; untreated chancres heal spontaneously within 6 to 8 wks, leaving a thin, depressed atrophic scar, signaling the end of the primary stage; T pallidum continues to multiply in the body and, untreated, give rise to secondary syphilis. See Congenital syphilis, Secondary syphilis.

pri·mar·y syph·i·lis

(prī'mar-ē sif'i-lis)
The first stage of syphilis.
See also: syphilis

pri·mar·y syph·i·lis

(prī'mar-ē sif'i-lis)
The first stage of syphilis.
References in periodicals archive ?
45) HRSA adds that some specialists recommend presumptive treatment for sex partners of people diagnosed with primary syphilis in the past 3 months, secondary syphilis in the past 6 months, or early latent syphilis in the past year.
How HIV may affect the course and treatment of syphilis * Higher RPR or T pallidum hemagglutination assay titer * False-negative syphilis serology * More frequent prozone phenomenon (* 68) * Higher rate of asymptomatic primary syphilis (66-68) * Multiple or deeper chancres during primary syphilis (69) * Overlap of primary- and secondary-stage features of syphilis (66,68) * Shorter latency period before meningovascular syphilis * Increased rate of early neurologic and ophthalmic involvement (66,68) * More rapid progression to tertiary manifestations (69) * Reduced efficacy of standard therapy for early syphilis ([dagger] 66) * More frequent relapse ([dagger] 68,70) * Delayed normalization of CSF values after treatment (69) Adapted from Pialoux et al.
The overall sensitivity of RPR to detect primary syphilis in our setting was 69.
As has been demonstrated previously in southern Africa, the utility of both treponemal and non-treponemal serological tests for the diagnosis of primary syphilis is questionable, (16) since many patients with primary syphilis are seronegative (especially by the RPR test), while others with ulcerations caused by other organisms are seropositive (especially by the FTA-ABS test) as a result of previously treated treponemal infections.
3% of patients with M-PCR-confirmed TP infection were found to be RPR-seropositive, and the rate of RPR seropositivity among primary syphilis patients co-infected with HIV (57.
Regardless of the underlying mechanism of this decrease in sensitivity, it is clear that caution should be exercised in the interpretation of syphilis serological testing in cases of GUD, particularly in those who are co-infected with HIV, because many cases of primary syphilis may be associated with other causes of GUD.
Primary syphilis presents as a painless chancre, which heals within 2 to 3 weeks.
In 1986, Fiumara (21) reported on 588 patients with primary syphilis and 623 patients with secondary syphilis.
The reaction occurs in up to 95% of treated cases of primary syphilis but is rare in treated late syphilis.
An evaluation of the relative sensitivities of VDRL and TP-PA among patients with darkfield-confirmed primary syphilis [Abstract 0641].