primary sclerosing cholangitis

Primary sclerosing cholangitis

A chronic disease in which it is believed that the immune system fails to recognize the cells that compose the bile ducts as part of the same body, and attempts to destroy them. It is not clear what exactly causes the disease, but it is frequently associated with another inflammatory disease of the digestive tract, ulcerative colitis. The inflammation of the ducts eventually produces formation of scar tissue, causing multiple areas of narrowing (strictures) that block bile flow and lead to bacterial infection. Liver transplant gives the best chance for long-term survival.

Mentioned in: Cholangitis

primary sclerosing cholangitis,

a progressive chronic fibrosing inflammation of the bile ducts of unknown cause, occurring most commonly in young men and frequently in association with chronic ulcerative colitis. It also occurs as a complication of HIV infection. See also AIDS cholangiopathy.

primary sclerosing cholangitis

Sclerosing cholangitis A chronic idiopathic progressive liver disease characterized by inflammation, necrosis, fibrosis and obliteration of intrahepatic and extrahepatic bile ducts, resulting in cholestasis, cirrhosis, portal HTN, liver failure, often associated with other autoimmune diseases–eg, Crohn's disease, ulcerative colitis, Addison's disease Epidemiology PSC is uncommon–1 to 6/105, US; it is the 4^th most common indication for liver transplant; 75% of Pts have IBD; 70% of Pts are ♂, average age 39 Clinical Often asymptomatic until end-stage liver disease; as albumin ↓ and BR ↑, pruritus, fatigue, jaundice, and weight loss dominate clinical picture, ± accompanied by fever, chills, night sweats, right upper quadrant pain Imaging Multiple zones of narrowing and dilatation– “beading” of bile duct by ERCP and transhepatic cholangiography Lab ↑ Alk phos, ↑ aminotransferase, hypergammaglobulinemia, ↑ IgM Management Azacytidine may ↓ need for transfusion, iron chelation–early use of deferiprone, corticosteroids, penicillamine, MTX; ursodiol is useless Prognosis Median survival after diagnosis, 12 yrs. See Primary biliary cirrhosis.

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AIDS cholangiopathy cholangitis liver transplant sclerosing cholangitis	When the bile ducts outside the liver become narrowed and blocked, the condition is called primary sclerosing cholangitis. Liver Cirrhosis-Symptoms and Causes Liver Cirrhosis by Peter Sams / Health, general community In addition, local areas of signal dropout can be caused by metallic clips following cholecystectomy, defects induced by the right hepatic artery crossing the bile duct, or from severely narrowed ducts, such as occurs in primary sclerosing cholangitis (PSC). Accuracy of MRCP compared with ERCP in the diagnosis of bile duct ... by Hurter, D.; De Vries, C.; Potgieter, P.H.; Barry, R.; Botha, F.J.H.; Joubert, G. / South African Journal of Radiology Evaluation of the liver parenchyma may reveal recurrent hepatic disease, as has been well documented in cases of viral hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and malignancy, such as hepatocellular carcinoma and cholangiocarcinoma. Ultrasound imaging of liver and renal transplantation by Piyasena, Rohan V.; Allison, Sandra J. / Applied Radiology	primary mental health care clinician primary nondisjunction primary nurse primary nursing primary oocyte primary organizer Primary osteoarthritis primary ovarian follicle primary palate primary pentosuria Primary personality primary physician primary pneumonic plague primary polycythemia primary prevention primary process primary processes Primary progressive primary progressive aphasia primary proximal RTA primary pulmonary lobule primary reaction primary relationships primary respiratory impulse primary response primary sclerosing cholangitis primary sensation primary sequestrum primary sex character primary sex characteristic primary shock Primary sleep disorder primary somatic dysfunction primary spermatocyte primary sterility primary symptoms primary syphilis primary teeth primary tooth primary triad primary tuberculosis primary tumor primary union primase primate Primates Primaxin prime prime mover primer primidone	primary ruminal tympany primary ruminal tympany primary ruminant gastrointestinal dysfunction primary ruminant gastrointestinal dysfunction primary ruminant gastrointestinal dysfunction primary ruminant gastrointestinal dysfunction Primary Russian Chronicle Primary salt Primary Sampling Unit primary scattering primary school primary school primary school Primary School Action for Better Health Primary School Education Programme Primary School Examination Primary School Leaving Certificate of Education Primary School Leaving Examination Primary School Mathematics Olympiad Primary School Performance Monitoring Project Primary School Teachers and Science Primary schools Primary schools Primary Schools Guitar Ensemble Primary Schools Learning Network Primary Schools Wind Ensemble Primary Science Enhancement Programme Primary Science Review Primary scientific literature Primary Scleroderma Myocardial Disease primary sclerosing cholangitis Primary Scrambling Code Primary Search Tonal primary seborrhea primary seborrhea primary seborrhea Primary Secretory Otitis Media Primary sector Primary sector of economic activity primary sectors primary sedimentary structure Primary Segmental Glomerulosclerosis and Hyalinosis primary sensation primary sensation primary sensation primary sensation Primary Sensorimotor Primary sensory cortex Primary sensory cortex Primary sensory cortex Primary septum Primary sequence Primary sequence primary sequestrum Primary service area Primary Service Node Primary Settling Tank primary sewage sludge primary sex c primary sex c primary sex c

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AIDS cholangiopathy
cholangitis
liver transplant
sclerosing cholangitis

When the bile ducts outside the liver become narrowed and blocked, the condition is called primary sclerosing cholangitis.

Liver Cirrhosis-Symptoms and Causes Liver Cirrhosis by Peter Sams / Health, general community

In addition, local areas of signal dropout can be caused by metallic clips following cholecystectomy, defects induced by the right hepatic artery crossing the bile duct, or from severely narrowed ducts, such as occurs in primary sclerosing cholangitis (PSC).

Accuracy of MRCP compared with ERCP in the diagnosis of bile duct ... by Hurter, D.; De Vries, C.; Potgieter, P.H.; Barry, R.; Botha, F.J.H.; Joubert, G. / South African Journal of Radiology

Evaluation of the liver parenchyma may reveal recurrent hepatic disease, as has been well documented in cases of viral hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and malignancy, such as hepatocellular carcinoma and cholangiocarcinoma.

Ultrasound imaging of liver and renal transplantation by Piyasena, Rohan V.; Allison, Sandra J. / Applied Radiology

primary mental health care clinician

primary nondisjunction

Primary osteoarthritis

primary ovarian follicle

primary palate

primary pentosuria

Primary personality