primary periodic paralysis


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to primary periodic paralysis: normokalemic periodic paralysis, hypokalemic periodic paralysis, Primary Hypokalemic Periodic Paralysis

primary periodic paralysis

The occurrence of intermittent weakness, usually following rest or sleep and almost never during vigorous activity. The condition usually begins in early life and rarely has its onset after age 25. The attacks may last from a few hours to a day or more. The patient is alert during an attack.

The causes include hypokalemia, hyperkalemia, thyrotoxicosis, and a form of paramyotonia. Both forms of the disease in which potassium regulation is a factor respond to acetazolamide. The thyrotoxicosis-related disorder is treated by correcting the underlying thyrotoxicosis. Spironolactone is the treatment for cases of paramyotonia congenita with periodic paralysis.

See also: paralysis
Full browser ?