primary hyperalgesia

primary hyperalgesia

increased sensation due to release of inflammatory mediators into peripheral tissues, subsequent to injury/infection; abnormally prolonged primary hyperalgesia contributes to general hyperalgesia
References in periodicals archive ?
In an animal model of mild hindpaw thermal injury, primary hyperalgesia developed in the region of the injury and was accompanied by secondary tactile allodynia in an uninjured area of the paw [9].
The evolution of primary hyperalgesia in orthopedic surgery: quantitative sensory testing and clinical evaluation before and after total knee arthroplasty.
Primary hyperalgesia is defined as changes in the area of injury, while secondary hyperalgesia is changes to pain thresholds in the undamaged tissue surrounding the injury, which can become hypersensitive to touch (Campbell et al.
Ketamine is known to reduce pro-inflammatory cytokine release (12) potentially reducing primary hyperalgesia.
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