Most patients with primary hemochromatosis
do not have involvement of the spleen; iron deposition in primary hemochromatosis
occurs in the parenchymal cells of the liver (hepatocytes), hence splenic signal intensity usually is normal in these patients where as in secondary hemochromatosis, iron deposition occurs in reticulo endothelial system (Kupffer cells and spleen).
Survival and causes of death in cirrhotic patients with primary hemochromatosis
However, in light of the intricate balance described above, it appears noteworthy that in the absence of a genetic condition called primary hemochromatosis
, the human body absorbs a mere 5% to 15% of ingested iron, even following acute blood (iron) loss.
Enhanced MR imaging of the shoulder, and sternoclavicular and acromioclavicular joint arthritis in primary hemochromatosis
Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis
Other causes of cystic splenic masses, such as parasitic cysts, various vascular tumors, fluid collections related to pancreatitis, benign tumors of the spleen, and cystic metastases, and the primary hemochromatosis
of spleen which show calcification.
CMS already covers, liver transplants for adults with primary biliary cirrhosis, primary sclerosing cholangitis, hepatitis B-related cirrhosis, and primary hemochromatosis
While infrequent, hemochromatosis may occur in ESRD patients: 1 in 300 Caucasians are homozygous for the gene for primary hemochromatosis
, and 1 in 10 are heterozygous (Bregman et al.
is believed to be a consequence of a genetically determined error of metabolism in which an unexplained increased absorption of iron occurs from the gastrointestinal tract.
9-12) Because primary hemochromatosis
is a common comorbid condition with diabetes, (13-15) most work on the relation between hemochromatosis and diabetes has focused on screening patients with diabetes for hemochromatosis.
in children: report of three new diagnosed cases and review of the pediatric literature.