primary generalized dystonia

primary generalized dystonia

a disorder, either familial or acquired, that usually begins in childhood or adolescence; manifested by muscular contractions that distort the spine, limbs, hips, and sometimes the cranial innervated muscles. The abnormal movements are increased by excitement and, at least initially, abolished by sleep. The musculature is hypertonic when in action, hypotonic when at rest. Hereditary forms usually begin with involuntary posturing of the foot or hand (autosomal recessive form [MIM*224500]) or of the neck or trunk (autosomal dominant form [MIM*128100]); both forms may progress to produce contortions of the entire body.
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To our knowledge, these two cases represent the longest duration of retained benefit in primary generalized dystonia.