primary outcome measure

(redirected from primary end point)

primary outcome measure

(1) The specific key measurement(s) or observation(s) used to measure the effect of experimental variables in a study, or for observational studies, to describe patterns of diseases or traits or associations with exposures, risk factors or treatment.
(2) The outcome measure or measures in a clinical trial which have the greatest or most desirable therapeutic effect.
References in periodicals archive ?
The primary end point was a composite of cardiac death, stroke, reinfarction, ventricular arrhythmia, or paroxysmal atrial fibrillation within 1 month.
ORLANDO -- Duloxetine for the treatment of late-life depression missed its primary end point in a recent large randomized trial, but it did result in consistently significant clinical improvement, compared with placebo across numerous secondary outcome measures.
For the primary end point, both mepolizumab treatment arms showed statistically significant reductions in the frequency of clinically significant exacerbations of asthma compared to placebo (75mg IV, 47%, p
The primary end point was a composite of myocardial infarction, stroke and death from cardiovascular causes.
At the end of treatment, only 2 participants in each treatment group achieved the prespecified primary end point.
The study's primary end point was freedom from overt or occult HBV infection with adequate immune response, defined as anti-HBs titers of at least 10 IU/mL, Dr.
CONCLUSIONS: In high-risk patients undergoing coronary artery bypass graft, treatment with MC-1 did not significantly affect the prespecified primary end point but was associated with a significant reduction in perioperative myocardial infarction with creatinine kinase-myocardial band > or =100 ng/mL.
This potential exists because Cymbalta only narrowly missed the defined primary end point of pain and global outcome in the only six-month clinical trial for which data are currently available (Chappell A, 2007).
The primary end point will be a clinical assessment of the treated skin areas using a severity index score.
Although neuroimmunophilin did not meet its primary end point and produce a significant reversal in the motor symptoms of Parkinson's disease, we were encouraged that it was well tolerated,'' Dr.
As a result of the study's progress, the company has adjusted its projections and now expects to have primary end point data for the EVEREST study available for submission to the FDA in the fourth quarter of 2007.
When the analysis was restricted to the 27% of patients who were not taking statin drugs at baseline, vitamin and mineral supplementation significantly decreased the primary end point by 38%.