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primary amebic meningoencephalitis

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primary amebic meningoencephalitis,
a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria and Acanthamoeba. Infection caused by Naegleria is generally seen in young persons who swim or bathe in contaminated freshwater, the pathogens gaining access to the central nervous system by penetrating the nasal mucosa and cribriform plate and then following the olfactory bulbs and nerves to the brain and meninges. By contrast, Acanthamoeba infections tend to be more benign, are more often seen in older or immunocompromised persons, and are sometimes associated with spontaneous recovery; the mode of transmission of these infections is not known, but hematogenous spread from amebic infection at distant sites has been reported.

meningoencephalitis [mĕ-ning″go-en-sef″ah-li´tis]
inflammation of the brain and its meninges; called also encephalomeningitis.
primary amebic meningoencephalitis a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria, Acanthamoeba, and Hartmannella.

primary amebic meningoencephalitis
An intracranial infection by free-living amoebae–eg, Naegleria fowleri, N grubei, Acanthamoeba, Hartmannella, Entamoeba histolytica, etc Clinical Acute, purulent meningoencephalitis–typically by Naegleria spp–in young healthy persons swimming in stagnant, artificial fresh water lakes; inflammation and hemorrhage is most intense along the olfactory tract, inculpating the cribriform plate as the portal of entry via the nose Prognosis Poor; the few Pts who survive are treated with parenteral amphotericin B, miconazole, rifampicin, and have major sequelae; PAM may also be subacute with a granulomatous reaction, a finding more common in immunocompromised hosts


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To the Editor: Naegleriafowleri, a protozoon found in hot springs and warm surface water, can cause primary amebic meningoencephalitis in humans.
Infection with Naegleria causes the disease primary amebic meningoencephalitis (PAM), a brain inflammation, which leads to the destruction of brain tissue.
PCR has been used to identify ameba DNA in brain tissue and CSF of persons suspected of having balamuthiasis (2) and in brain tissue of a patient with primary amebic meningoencephalitis caused by N.
 
 
 
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