primary amebic meningoencephalitis


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to primary amebic meningoencephalitis: Naegleria fowleri

meningoencephalitis

 [mĕ-ning″go-en-sef″ah-li´tis]
inflammation of the brain and its meninges; called also encephalomeningitis.
primary amebic meningoencephalitis a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria, Acanthamoeba, and Hartmannella.

pri·mar·y a·me·bic me·nin·go·en·ceph·a·li·tis

an invasive, rapidly fatal cerebral infection by soil amebae, chiefly Naegleria fowleri, found in humans and other primates and experimentally in rodents; the disease is characterized by a high fever, neck rigidity, and symptoms associated with upper respiratory infection such as cough and nausea; although organisms have been cultured from various organs, the brain is the primary focus, especially the olfactory lobes and cerebral cortex, which are first attacked by amebae that enter from nasal mucosa through the cribriform plate; death usually occurs 2-3 days after onset of symptoms.

primary amebic meningoencephalitis

a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria and Acanthamoeba. Infection caused by Naegleria is generally seen in young persons who swim or bathe in contaminated freshwater, the pathogens gaining access to the central nervous system by penetrating the nasal mucosa and cribriform plate and then following the olfactory bulbs and nerves to the brain and meninges. By contrast, Acanthamoeba infections tend to be more benign, are more often seen in older or immunocompromised persons, and are sometimes associated with spontaneous recovery; the mode of transmission of these infections is not known, but hematogenous spread from amebic infection at distant sites has been reported.

primary amebic meningoencephalitis

An intracranial infection by free-living amoebae–eg, Naegleria fowleri, N grubei, Acanthamoeba, Hartmannella, Entamoeba histolytica, etc Clinical Acute, purulent meningoencephalitis–typically by Naegleria spp–in young healthy persons swimming in stagnant, artificial fresh water lakes; inflammation and hemorrhage is most intense along the olfactory tract, inculpating the cribriform plate as the portal of entry via the nose Prognosis Poor; the few Pts who survive are treated with parenteral amphotericin B, miconazole, rifampicin, and have major sequelae; PAM may also be subacute with a granulomatous reaction, a finding more common in immunocompromised hosts
References in periodicals archive ?
PCR has been used to identify ameba DNA in brain tissue and CSF of persons suspected of having balamuthiasis (2) and in brain tissue of a patient with primary amebic meningoencephalitis caused by N.
We report the first case of primary amebic meningoencephalitis in Italy, in a 9-year-old boy.

Full browser ?