primary amebic meningoencephalitis

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Related to primary amebic meningoencephalitis: Naegleria fowleri


inflammation of the brain and its meninges; called also encephalomeningitis.
primary amebic meningoencephalitis a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria, Acanthamoeba, and Hartmannella.

pri·mar·y a·me·bic me·nin·go·en·ceph·a·li·tis

an invasive, rapidly fatal cerebral infection by soil amebae, chiefly Naegleria fowleri, found in humans and other primates and experimentally in rodents; the disease is characterized by a high fever, neck rigidity, and symptoms associated with upper respiratory infection such as cough and nausea; although organisms have been cultured from various organs, the brain is the primary focus, especially the olfactory lobes and cerebral cortex, which are first attacked by amebae that enter from nasal mucosa through the cribriform plate; death usually occurs 2-3 days after onset of symptoms.

primary amebic meningoencephalitis

a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria and Acanthamoeba. Infection caused by Naegleria is generally seen in young persons who swim or bathe in contaminated freshwater, the pathogens gaining access to the central nervous system by penetrating the nasal mucosa and cribriform plate and then following the olfactory bulbs and nerves to the brain and meninges. By contrast, Acanthamoeba infections tend to be more benign, are more often seen in older or immunocompromised persons, and are sometimes associated with spontaneous recovery; the mode of transmission of these infections is not known, but hematogenous spread from amebic infection at distant sites has been reported.

primary amebic meningoencephalitis

An intracranial infection by free-living amoebae–eg, Naegleria fowleri, N grubei, Acanthamoeba, Hartmannella, Entamoeba histolytica, etc Clinical Acute, purulent meningoencephalitis–typically by Naegleria spp–in young healthy persons swimming in stagnant, artificial fresh water lakes; inflammation and hemorrhage is most intense along the olfactory tract, inculpating the cribriform plate as the portal of entry via the nose Prognosis Poor; the few Pts who survive are treated with parenteral amphotericin B, miconazole, rifampicin, and have major sequelae; PAM may also be subacute with a granulomatous reaction, a finding more common in immunocompromised hosts
References in periodicals archive ?
Unspecified neuroinfectious death ICD-10 codes by epidemiologic risk factor for primary amebic meningoencephalitis among persons 2-22 years of age, United States, 1999-2010 * ([dagger]) ICD-10 code, disease Total In high-incidence states ([double dagger]) (%) G03.
Production of monoclonal antibodies to Naegleria fowleri, agent of primary amebic meningoencephalitis.
fowleri, is known to infect humans by causing an acute, usually lethal, central nervous system (CNS) infection known as primary amebic meningoencephalitis (PAM).
Author's Note following the completion of this article: In 2011, two fatal cases of primary amebic meningoencephalitis (PAM) were reported in Louisiana from St.
7, 8) Table 1 contrasts clinical, diagnostic laboratory, and neuroimaging features of primary amebic meningoencephalitis with the only two known causes of granulomatous amebic encephalitis, Acanthamoeba and Balamuthia mandrillaris.
Neuroimaging studies by axial computerized tomography (CT) and/or magnetic resonance imaging (MRI) in BAE are nonspecific and often include single to multiple space-occupying lesions in the brain from the frontal cortex to the cerebellum with ring--enhancing and other focal effects slightly more common in balamuthiasis than in other free-living amebic infections of the brain, such as acanthamoebiasis and primary amebic meningoencephalitis (PAM).
General information, clinical features, diagnosis, recommended treatment, and risk reduction measures for primary amebic meningoencephalitis (PAM) General information * Naegleria fowleri, the thermophilic, free-living ameba that casues PAM, is common worldwide in warm freshwater bodies, including lakes, ponds, rivers, and hot springs; N.
Epidemiology, diagnosis, treatment, and prevention of primary amebic meningoencephalitis (PAM) attributed to Naegleria fowleri
PCR has been used to identify ameba DNA in brain tissue and CSF of persons suspected of having balamuthiasis (2) and in brain tissue of a patient with primary amebic meningoencephalitis caused by N.
Of the 30 reported outbreaks, 13 were of folliculitis; another 13, gastroenteritis, five of which were shigellosis; one, hepatitis A; and three were individual cases of primary amebic meningoencephalitis.
Three boys were reported to have died from primary amebic meningoencephalitis due to Naegleria.
Primary amebic meningoencephalitis (PAM) is invariably an acute, often fulminant infection caused by Naegleria fowleri, a small, free-living ameba that occasionally infects humans and other mammals.

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