prickle cell layer


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Related to prickle cell layer: malpighian layer, acanthosis

strat·um spi·no·sum ep·i·derm·i·dis

the layer of polyhedral cells in the epidermis; shrinkage artifacts and adhesion of these cells at their desmosomal junctions gives a spiny or prickly appearance.

prickle cell layer

stra·tum spi·no·sum ep·i·derm·i·dis

(strā'tŭm spī-nō'sŭm ep-i-dĕrm'i-dis)
The layer of polyhedral cells in the epidermis; shrinkage artifacts and adhesion of these cells at their desmosomal junctions give a spiny or prickly appearance.
Synonym(s): prickle cell layer, spinous layer.

stratum spinosum

; prickle cell layer enzyme-rich suprabasal layer of epidermis; lies between stratum basale and stratum granulosum Table 1
Table 1: Constituents of skin
ConstituentComponents
EpidermisStratified squamous epithelium formed from keratinocytes
Basal layer: keratinocytes linked by desmosomal and hemidesmosomal and filamentous connections (cytoskeleton; prevents shear)
Spinous layer: keratinocytes shrink, retaining contact only at desmosomes and hemidesmosomes
Granular layer: keratinocytes secrete complex lipids which act as a semipermeable skin barrier
Corneal layer: cell and contents have become keratin to form squames moved towards the exterior
Epidermal cellsKeratinocytes
Melanocytes: lie between keratinocytes; secrete pigment and protect keratinocyte nuclei from ultraviolet radiation
Merkel cells: sensory cells
Langerhans cells: within spinous layer; antigen-presenting cells
Basement membrane zoneCollagen, hemidesmosomes, laminin which aid adhesion of epidermis to dermis; dysfunctional in disease such as epidermolysis bullosa
DermisMesodermal tissue containing blood vessels, nerve, muscle, skin appendages (sweat glands, sebaceous glands, hair follicles), immune cells (histamine-releasing mast cells) in a matrix of collagen, elastin and hyaluronic acid
Subcutaneous layerAdipose tissue, blood vessels and nerves, acting as an insulating layer