Another explanation is the modulation of neuromuscular transmission, due to lowered number of vesicles fused with the presynaptic membrane
and quantal size of acetylcholin (ACh) per vesicle (Reid et al.
Choline is recycled by an active pump at the presynaptic membrane
for the formation of more acetylcholine.
A neuromuscular junction is comprised of three components--the presynaptic membrane
, the synaptic cleft, and the postsynaptic membrane.
5 nm/msec, which is not far from the right order of magnitude, bearing in mind the distances of the vesicles from the presynaptic membrane (3) and the exocytosis process times.
2+] channels and the subsequent presynaptic exocytosis of the neurotransmitter, contained in vesicles whose protein p65 interacts with the syntaxins of the active zone of the presynaptic membrane.
1] Autoreceptors on the presynaptic membrane, or even the presynaptic cell body, are often indirect and regulate transmitter release.
1D] may be autoreceptors on the presynaptic membrane as well postsynaptic receptors and have the same inhibitory function on adenylyl cyclase.
2]-adrenergic receptors that exist on the presynaptic membrane
of both serotonergic (i.
When the endorphin system is activated, opiate receptor sites are filled with endorphins that block the release and slow the production of chemical messengers of pain (substance P) from the presynaptic membrane
LX6171 is an orally-bioavailable small molecule developed by Lexicon scientists to inhibit a membrane protein expressed exclusively in the central nervous system and found at synaptic vesicles and presynaptic membranes
of glutamatergic neurons.
LX6171 is a selective and potent inhibitor of a novel membrane protein that is expressed exclusively in the central nervous system and is associated with synaptic vesicles and presynaptic membranes
Its activity is associated with synaptic vesicles and presynaptic membranes