aggressive periodontitis type 1

(redirected from prepubertal periodontitis)

aggressive periodontitis type 1

An autosomal dominant condition (OMIM:170650) characterised by severe and protracted gingival infections, leading to tooth loss.

Molecular pathology
Defects in CTSC, which encodes cathepsin C, a ubiquitous lysosomal cysteine proteinase, cause aggressive periodontititis type 1.
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References in periodicals archive ?
Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia.
Scientists have now discovered that different mutations of the same gene are responsible for the gum disorder called prepubertal periodontitis.
Molecular basis for the functional abnormality in neutrophils from patients with generalised prepubertal periodontitis.
Prepubertal periodontitis affecting the deciduous and permanent dentition in a patient with cyclic neutropenia: A case report and discussion.
Mutations of the cathepsin C gene have also been reported in patients with prepubertal periodontitis, which is characterized by a periodontal condition similar to PLS periodontitis, albeit without the dermatological symptoms.