This investigation unearthed seven essential human nonhomologous metabolic proteins, of which three were membranous proteins including preprotein
translocase subunit SecD (T1, gene reference 218562707), cbb3-type cytochrome c oxidase subunit I (T2, gene reference 218563091) and preprotein
translocase subunit SecE (T3, gene reference 218562127).
2234 2104679 T T G SP70585_2289 Position Gene product Synonymous 384518 Hypothetical protein No 425383 Helicase, RecD/TraA family No 457503 Not applicable -- 568204 Not applicable -- 923459 Dihydroorotate dehydrogenase 1B No 936681 Competence protein No 1389846 Pyridoxal biosynthesis lyase PdxS No 1675901 Preprotein
translocase subunit SecY No 2044455 # beta-N-Acetylglucosaminidase/ No beta-glucosidase (3- beta-N-acetyl-D- glucosaminidase/ beta-D-glucosidase) (Nag3) 2104679 alpha-L-Fucosidase No Position Amino acid change 384518 K [right arrow] * 425383 R [right arrow] H 457503 -- 568204 -- 923459 S [right arrow] A 936681 K [right arrow] N 1389846 E [right arrow] * 1675901 T [right arrow] I 2044455 # E [right arrow] A 2104679 S [right arrow] R # SNV is located in the genomic island.
Amyloid-[beta]-peptide induces mitochondrial dysfunction by inhibition of preprotein
maturation," Cell Metabolism, vol.
Eleven SNPs were shared only by Papworth and Seattle cystic fibrosis outbreak strains (n = 9), including nonsynonymous mutations in the preprotein
translocase secA1 and a putative lyase (Figure 2; online Technical Appendix).
Indeed, through screening of the human protein database, we found several secretory proteins that have similar T(or S)-X(n)-RXXR [down arrow] sequences, including endothelin 1 pre-prohormone (40TPSPPWRLRRSIR 2 C) and von Willebrand factor preprotein
(768SHRSKR [down arrow] S).
The six additional Nematostella loci that exhibit significant similarity to the "fibronectin type II" domain are best matches to human notch 2 preprotein
, relaxin, vitrin, neuronal pentaxin, neuropilin, and semaphorin.
In this preprotein
world, RNA served the role of both DNA (informational) and proteins (catalytic).
02 hevein preprotein
protein (latex coagulation) Hev b 6.
Epitopes in the hevein preprotein
are recognized by latex-allergic individuals previously unidentified.
NM_014080) is 6376 nucleotides long, and the preprotein
is composed of a putative 26-amino acid signal peptide followed by a 1522-amino acid polypeptide (31).
The "RNA World" hypothesis describes a preprotein
world where RNA was able to both carry genetic information (later evolved into DNA) and act as biocatalysts (most of them replaced by proteins).
Recognition of preproteins
by the isolated TOM complex of mitochondria," The EMBO Journal, vol.