preprotein

preprotein

 [pre-pro´tēn]
a protein precursor that contains a signal peptide sequence; it is a nonpolar sequence at the head of the growing polypeptide chain and is required for its transfer into the cistern of the endoplasmic reticulum; the signal sequence is then cleaved to form the protein or proprotein.

pre·pro·tein

(prē-prō'tēn),
A secretory protein with a signal peptide region attached.
References in periodicals archive ?
Eleven SNPs were shared only by Papworth and Seattle cystic fibrosis outbreak strains (n = 9), including nonsynonymous mutations in the preprotein translocase secA1 and a putative lyase (Figure 2; online Technical Appendix).
Indeed, through screening of the human protein database, we found several secretory proteins that have similar T(or S)-X(n)-RXXR [down arrow] sequences, including endothelin 1 pre-prohormone (40TPSPPWRLRRSIR 2 C) and von Willebrand factor preprotein (768SHRSKR [down arrow] S).
In this preprotein world, RNA served the role of both DNA (informational) and proteins (catalytic).
NM_014080) is 6376 nucleotides long, and the preprotein is composed of a putative 26-amino acid signal peptide followed by a 1522-amino acid polypeptide (31).