preparative regimen

preparative regimen

High doses of cancer chemotherapy and/or radiation therapy, used prior to bone marrow or cord blood transplantation to eliminate the recipient's blood-forming cells. Very high doses of drugs and/or radiation are used to eliminate as many diseased cells from the recipient's marrow as possible. As a result, the recipient's normal blood cells are also destroyed. Preparative regimens temporarily make patients immunodeficient, anemic, and platelet–deficient. Immunocompetence and the ability to form red cells and platelets are restored to patients when the donated stem cells they receive engraft, i.e., begin to repopulate and reproduce in the marrow. Also known as conditioning regimen.
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To examine whether transplant could be a safe and effective approach for HAL patients, researchers from the National Cancer Institute Bone Marrow Transplant Clinical Trials Network working in collaboration with the AIDS Malignancy Consortium, conducted a large, multi-center study among 40 patients with controlled HIV infection receiving autologous stem cell transplants with a high-dose preparative regimen.
Four weeks later she had a stem cell allograft using an unrelated donor with a preparative regimen of busulfan and cyclophosphamide.
For the majority of unrelated transplants following a standard high-dose preparative regimen, bone marrow should be used since survival is equivalent with two sources but the incidence of chronic graft-versus-host disease, which can be a debilitating complication, is significantly less with marrow," Dr.
Before the injection, patients undergo an immunodepleting preparative regimen to eliminate competing T regulatory cells and lymphocytes.
Because parking is not free at our facility, each patient receives two free books of parking passes when they start their preparative regimen.
Busulfan is commonly used in the preparative regimen prior to transplant.
Consolidative therapy consisted of an autologous peripheral-blood stem-cell transplant (auto PBSCT) with a preparative regimen of cyclophosphamide, carmustine (BCNU), and etoposide (CBV).
Safety of PK-guided IVBUCyVP-16 preparative regimen prior to autologous hematopoietic stem cell transplantation for lymphoma: findings from a multi-center phase II study in North America
Funds Will Support Research Into Safety and Efficacy of Genetically Unmatched Cord Blood Stem Cell Transplantations Using a Myeloablative Preparative Regimen.
Busulfan is a myeloablative agent that is used in combination with cyclophosphamide as a preparative regimen for bone marrow transplantation; high-dose busulfan can be used as a substitute for total body irradiation.
It is very encouraging to see the publication of long-term clinical data showing that ZEVALIN's usage in this allogeneic transplantation regimen can contribute to improved overall survival in the abysmal prognostic group of patients with disease progression after multiple chemotherapy regimens and in some cases, even with the standard preparative regimen used in autologous stem cell transplantation," stated Rajesh C.

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