It has also been shown in vitro that SrRan increases the synthesis of collagen and noncollagenous proteins, improves the proliferation of preosteoblast
cells, and that it should, therefore, be classified as a bone-forming agent (20).
maxima potently stimulated osteoblastic differentiation and mineralization of MC3T3-E1 preosteoblast
cells from mouse calvaria compared both with normal mineralizing medium and dexamethasone (Rousseau et al.
Three-dimensional printed scaffolds with gelatin and platelets enhance in vitro preosteoblast
growth behavior and the sustained-release effect of growth factors.
2] nanotube layers on MC3T3-E1 preosteoblast
adhesion, proliferation, and differentiation.
2011) found that 20 [micro]M PD98059 potentially induced rat preosteoblast
differentiation, whereas Bai et al.
Relationships between cellular condensation, preosteoblast
formation and epithelialmesenchymal interactions in initiation of osteogenesis.
In this study, detection based on cytotoxicity test standards in vitro showed that preosteoblast
proliferation increased rapidly in the early stage (days 1–5) and then the velocity decreased; we can see the results in [Figure 5].
The roles of PI3K/Akt signaling pathway in regulating MC3T3-E1 preosteoblast
proliferation and differentiation on SLA and SLActive titanium surfaces", J.
2008) found that icariin upregulated the ALP mRNA level dose-dependently in MC3T3-E1 preosteoblast
HEPM cells demonstrated the ability to differentiate from a preosteoblast
cell to an osteoblast over a 3-week time course .
cell lines MC3T3-E1 was obtained from American Type Culture Collection (ATCC).
By further osteogenic differentiation, it shapes into the preosteoblast