The roles of PI3K/Akt signaling pathway in regulating MC3T3-E1 preosteoblast
proliferation and differentiation on SLA and SLActive titanium surfaces", J.
2011) found that 20 [micro]M PD98059 potentially induced rat preosteoblast
differentiation, whereas Bai et al.
HEPM cells demonstrated the ability to differentiate from a preosteoblast
cell to an osteoblast over a 3-week time course .
2008) found that icariin upregulated the ALP mRNA level dose-dependently in MC3T3-E1 preosteoblast
cell lines MC3T3-E1 was obtained from American Type Culture Collection (ATCC).
By further osteogenic differentiation, it shapes into the preosteoblast
Runx 2 is required for mesenchymal cell differentiation into preosteoblasts
(Zhang 2010), whereas osterix--the osteoblast-specific transcription factor--is essential for the differentiation of preosteoblasts
into mature osteoblasts (Komori 2006).
The initial hematoma is replaced very rapidly by moderately dense fibrous tissue containing predominately type III collagen that is produced by fibroblastic cells and preosteoblasts
RANKL is highly expressed on the surface of bone marrow stromal cells (BMSCs) and preosteoblasts
(Ikeda et al.
Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts