Hypothyroidism or premature thelarche were detected in 2 children.
n (%) Overweight 8 21 Obesity 6 16 Hyperlipidemia 8 21 Insulin resistance 2 5 Osteopenia 2 5 Premature thelarche 1 3
Consumption of chicken raised on such hormones was no higher in families with girls experiencing premature thelarche
than in those where girls developed normally.
Polybrominated biphenyls (PBBs) were found to be associated with premature thelarche in girls who were breast-fed by mothers with high serum PBB levels ([greater than or equal to] 7 [micro]g/L) resulting from exposure to milk from cows given contaminated feed (Blanck et al.
In a case-control study, the intake of soy-based formula was associated with an increased likelihood of premature thelarche in children younger than 2 years but not in children diagnosed with thelarche beyond this age (Freni-Titulaer et al.
However, when they compared the blood of 41 girls with premature thelarche with that of 35 who are developing normally, "we did not find pesticides or their metabolites at higher levels," notes University of Puerto Rico chemist Osvaldo Rosario.
Within the premature thelarche group, 24 girls (68 percent) had detectable phthalates in their blood, compared with just 6 (17 percent) of the girls developing normally.
2000), the blood samples were taken from children after referral to pediatric clinics, that is, after premature thelarche had been observed.
There is a hypothesis that premature thelarche is a consequence of unintentional exposure to estrogen or estrogen-like substances (e.
Human studies are scarce, but a recently published case-control study examined the association between premature thelarche
(premature breast development) and phthalate exposure among girls 6 months to 8 years of age (Colon et al.
in Puerto Rico: a search for environmental estrogenic contamination.
Puerto Rico has the highest known incidence of premature thelarche