premature senescence


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premature senescence

Aging (typically of cells, but also of whole organisms) that occurs much earlier than is expected under healthy or optimal conditions.
See also: senescence
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References in periodicals archive ?
In the present study, we investigated the effects of GlcN on H[sub]2O[sub]2-induced premature senescence and the mechanisms underlying its effects in human RPE cells.
Hence, additional studies are needed to investigate the details of the mechanisms by which GlcN reduces H[sub]2O[sub]2-induced premature senescence and the processes involved in AMD.
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes.
Premature senescence of endothelial cells: Methusaleh's dilemma.
On the basis of the similarity between Atg7-deficient and vitiligo phenotypes, specifically with respect to the activation of Nrf2 regulated genes, oxidative stress, and premature senescence, it is very likely that autophagy-deficient melanocytes and vitiligo melanocytes share defective cellular redox regulation, increased membrane lipid oxidation, and premature senescence [65].
Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes," Journal of Investigative Dermatology, vol.
Validation of the In Vitro Model System of Premature Senescence of IVD Cells.
We developed an in vitro model system of premature senescence of IVD cells, induced by sublethal oxidative stress.
Kletsas, "Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells," European Cells & Materials, vol.
2]-induced premature senescence in primary human keratinocytes," PLoS ONE, vol.

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