A separate group of rats received optogenetic stimulation of a different brain region, the prelimbic
prefrontal cortex (PrL-PFC).
The researchers at the Kavli Institute showed that a similar code is present in nucleus reuniens (NR) in the thalamus as well as anterior cingulate (AC) and prelimbic
cortex (PC), both in the medial prefrontal cortex (mPFC).
Zelikowsky said she found it interesting that sub-regions in the prefrontal cortex compensated in different ways, with one sub-region - the infralimbic cortex - silencing its activity and another sub-region - the prelimbic
cortex - increasing its activity.
Then the researchers sent electric current through neurons in an area of the rats' prelimbic
cortex that links to other brain areas involved in drug-seeking behaviors.
Recent studies implicate the prelimbic
cortex in fear expression as well, by way of its connection to the basal and then to central nucleus of amygdale.
When we turn on a laser light in the prelimbic
region of the prefrontal cortex, the compulsive cocaine seeking is gone," Antonello Bonci, senior author and scientific director of the intramural research program at the National Institute of Drug Abuse, said in a statement.
division of the mPFC (PL) is important in stress inhibition because numerous studies have shown that damage to this region prolongs HPA axis responses to acute psychogenic (but not homeostatic) stressors (Diorio et al.
In that study, rats with neurotoxic lesions of the prelimbic
area (PL) were given a choice between familiar lab chow and a novel, preferred food in an unfamiliar, open field environment.
administration of EGb 761 (Exp 2) also significantly increased Fos-IR in several brain regions including the prelimbic
The role of prelimbic
cortex in instrumental conditioning.
A behavioural analysis of the delayed nonmatching to position task: The effects of scopolamine, lesions of the fornix and of the prelimbic
region on mediating behaviours by rats.
The Contribution of the Prelimbic
Cortex, Orbitofrontal Cortex and Dorsomedial Striatum to Behavioral Flexibility