The mPFC is additionally divided into the infralimbic cortex, prelimbic
cortex, and dorsal anterior cingulate.
Different current intensities electrical stimulation of prelimbic
cortex of mPFC produces different effects on morphine-induced conditioned place preference in mts.
Brain functional network changes following Prelimbic
area inactivation in a spatial memory extinction task.
Miguel-Hidalgo, "Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic
cortex of alcohol-preferring rats," Alcohol and Alcoholism, vol.
A separate group of rats received optogenetic stimulation of a different brain region, the prelimbic
prefrontal cortex (PrL-PFC).
The researchers at the Kavli Institute showed that a similar code is present in nucleus reuniens (NR) in the thalamus as well as anterior cingulate (AC) and prelimbic
cortex (PC), both in the medial prefrontal cortex (mPFC).
20 mm for the infralimbic cortex (IL), prelimbic
cortex (PL), the cingulate cortex (CG); -1.
Zelikowsky said she found it interesting that sub-regions in the prefrontal cortex compensated in different ways, with one sub-region - the infralimbic cortex - silencing its activity and another sub-region - the prelimbic
cortex - increasing its activity.
Then the researchers sent electric current through neurons in an area of the rats' prelimbic
cortex that links to other brain areas involved in drug-seeking behaviors.
Recent studies implicate the prelimbic
cortex in fear expression as well, by way of its connection to the basal and then to central nucleus of amygdale.
When we turn on a laser light in the prelimbic
region of the prefrontal cortex, the compulsive cocaine seeking is gone," Antonello Bonci, senior author and scientific director of the intramural research program at the National Institute of Drug Abuse, said in a statement.
Further studies are ongoing that seek to determine whether differences exist in the activation of some structures of the prefrontal cortex, such as prelimbic
and cingulate regions.