preleukemia


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Related to preleukemia: Myelodysplastic syndrome

preleukemia

 [pre″loo-ke´me-ah]
a stage of bone marrow dysfunction preceding the development of acute myelogenous leukemia. adj., adj preleuke´mic.

myelodysplastic syndrome

a heterogeneous group of clonal hematopoietic stem cell disorders characterized by the presence of dysplastic changes in one or more of hematopoietic lineages. The common clinical picture may include anemia, infections, and bleeding problems. Occurs generally in elderly patients, or those with prior exposure to leukemogenic agents. Transformation rates to acute leukemia range from 10-80%. Cytogenetic abnormalities are associated with a poor prognosis.

preleukemia

/pre·leu·ke·mia/ (pre″loo-ke´me-ah) myelodysplastic syndrome.preleuke´mic

preleukemia

Myelodysplastic syndrome, smoldering leukemia Any of a heterogeneous group of clonal expansions of stem cells, characterized by dysmyelopoiesis–a complex of structural and functional defects–eg, abnormal cell morphology, ineffective hematopoiesis, chromosome defects–eg, aneuploidy and pseudodiploidy Examples Acquired idiopathic sideroblastic and nonsideroblastic anemias, pancytopenia with hypercellular marrow, paroxysmal nocturnal hemoglobinuria, which may all progress to ANLL

my·e·lo·dys·plas·tic syn·drome

(mī'ĕ-lō-dis-plast'ik sin'drōm)
A primary, neoplastic, pluripotential stem cell disorder characterized by peripheral blood cytopenias and prominent maturation abnormalities in the bone marrow. The disease evolves progressively and may transform into leukemia. Classified by the French-American-British (FAB) system (q.v.) into five groups.
Synonym(s): chronic erythremic myelosis, preleukemia, smoldering leukemia.

preleukemia

a stage of bone marrow dysfunction which may progress to the development of granulocytic leukemia. It occurs in cats which in most cases are infected by feline leukemia virus. The disease is also called subleukemic granulocytic leukemia.
References in periodicals archive ?
Human preleukemia : identification of a maturation defect in vitro.
Myelodysplastic syndrome is a disease in which the bone marrow does not function normally and is sometimes referred to as preleukemia or "smoldering leukemia".
Hexagonal crystals in the bone marrow of patients with myeloproliferative disease and preleukemia.
Leukemia and preleukemia in Fanconi anemia patients: a review of the literature and report of the International Fanconi Anemia Registry.
After conducting genetic analyses of 13 patients with leukemia or preleukemia syndromes, she and her colleagues concluded that the gene for this regulatory protein lies on the stretch of chromosome 5 found faulty in many people with leukemia.
Roberts, 51, who previously battled breast cancer in 2007, announced in early June that she had been diagnosed with a rare disorder called myelodysplastic syndrome, known in the past as preleukemia.