prekallikrein

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prekallikrein /pre·kal·li·kre·in/ (-kal-i-kre´in) the proenzyme of plasma kallikrein; it is cleaved and activated by coagulation factor XII.

prekallikrein,

n a plasma protein that is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. Prekallikrein deficiency leads to Fletcher factor deficiency, a congenital disease.

prekallikrein

fletcher factor in blood coagulation. Precursor of plasma kallikrein which circulates in the blood. Acts in the initiation of intrinsic coagulation.

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