prekallikrein


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Related to prekallikrein: High molecular weight kininogen

prekallikrein

 [pre-kal″ĭ-kre´in]
a plasma protein that is the proenzyme of plasma kallikrein; it is cleaved to its active enzyme form by activated coagulation factor XII.

pre·kal·li·kre·in

(prē'kal-ĭ-krē'in),
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII. Prekallikrein also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor

prekallikrein

/pre·kal·li·kre·in/ (-kal-ĭ-kre´in) the proenzyme of plasma kallikrein; it is cleaved and activated by coagulation factor XII.

prekallikrein

[prekal′ikre′in]
a plasma protein that is the proenzyme of plasma kallikrein. It is cleaved to its active enzyme form by activated coagulation factor XII.

pre·kal·li·kre·in

(prē'kal-i-krē'in)
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII; also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor.

Fletcher,

surname of the patient in whom the defect was first noted.
Fletcher defect - slow contact activation in coagulation of the blood.
Fletcher factor - factor found in coagulation studies, revealing a slow contact activation but not associated with bleeding abnormalities. Synonym(s): prekallikrein

pre·kal·li·kre·in

(prē'kal-i-krē'in)
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII; also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor.

prekallikrein,

n a plasma protein that is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. Prekallikrein deficiency leads to Fletcher factor deficiency, a congenital disease.

prekallikrein

fletcher factor in blood coagulation. Precursor of plasma kallikrein which circulates in the blood. Acts in the initiation of intrinsic coagulation.
References in periodicals archive ?
Activated factor XII converts prekallikrein into kallikrein, and the latter cleaves high-molecular-weight kininogen into bradykinin, which mediates many of the biologic effects of this system.
Fibrinogen Vitamin K-dependent Contact Fibrinogen Factor II Factor XII Factor V Factor VII HMWKa Factor VIII Factor IX Prekallikrein (b) Factor XIII Factor X Factor XI (a) HMWK, high-molecular weight kininogen, also known as Fitzgerald factor.
Excessive hemostatic activation may be related to the interaction of the contact factors XII and XI, high-molecular-mass kininogen, and prekallikrein with the extensive CPB surfaces [7], and activation of the extrinsic pathway [8] secondary to surgical trauma or retransfusion of pericardial blood [9].