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A steroid that serves as an intermediate in the biosynthesis of numerous hormones, including progesterone. Serum levels are elevated in a rare form of congenital adrenal hyperplasia.


/preg·ne·no·lone/ (preg-nēn´ŏ-lōn) an intermediate in steroid hormone synthesis.

pregnenolone (preg·neˑ·n·lōn),

n a precursor to steroid hormones that is synthesized (endogenously) from cholesterol or (exogenously) from soybeans. Has been used in a host of conditions including Alzheimer's disease, menopausal complaints, Parkinson's disease, osteoporosis, fatigue, stress, memory loss, and other conditions. May interact with the use of supplemental steroid hormones.


a precursor in the synthesis of steroid hormones, formed from cholesterol.
References in periodicals archive ?
Pregnenolone also is produced by the adrenal glands and is important in regulating the adaptive homeostat.
Pain management clinics, for example, are increasingly using LC-MS/MS methods to quantify hormones such as pregnenolone, 17alpha-hydroxypregnenolone, and cortisone in patient serum.
Pregnenolone prevents THC, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC causes the intoxicating effects of cannabis.
The potent species-specific PXR ligands rifampicin (RIF) and pregnenolone l6[alpha]-carbonitrile (PCN) were used as the positive control for hPXR and mPXR, respectively.
Pregnenolone is the most abundant hormone in the brain--considered to be the "grandmother" hormone, one from with all others are derived.
Merritt, who also won the world 400m title in Berlin last year, admitted using an over-thecounter male enhancement product containing DHEA (dehydroepiandrosterone) and pregnenolone.
They found that this protective effect can be triggered by pregnenolone sulphate - a molecule that is part of a family of 'fountain-of-youth' steroids.
19) Darnaudery M, Koehl M, Piazza PV, et al Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition.
Naturally occurring anabolic steroids are synthesized in the testis, ovary and adrenal gland from cholesterol via pregnenolone.
Diosgenin is isolated from these plants and is converted in the lab to all of the human hormones: estradiol, estriol, estrone, progesterone, testosterone, DHEA, and pregnenolone.
It thus appears that this enzyme is involved in the synthesis of pregnenolone and progesterone in villous syncytiotrophoblast which seems to be the major site of steroid hormone synthesis in rhesus monkey.
These products may contain hormones including: estrone, estradiol, estriol, DHEA, progesterone, pregnenolone, and testosterone.