preglomerular

preglomerular

/pre·glo·mer·u·lar/ (-glo-mer´u-lar) located or occurring proximal to a renal glomerulus.
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Pathophysiology of drug-induced nephropathy Level of the nephron Action Drugs Preglomerular Afferent arteriolar Cyclosporine (afferent arteriole) constriction Glomerulus Decreased GFR NSAIDs (prostaglandins) Gold, NSAIDs Glomerulonephritis Penicillamine, cisplatin Proximal tubules Acute tubular necrosis Aminoglycosides, radiocontrast dyes Distal tubules Renal tubular ACE inhibitors, acidosis type 4 cyclosporine Tubules and ducts Crystalluria Acyclovir, sulphonamide Interstitium Interstitial nephritis Penicillin, allopurinol Renal papilla Papillary necrosis NSAIDs, analgesics Table 2.
This is accomplished through a myogenic reflex inherent to the kidney, wherein the preglomerular vasculature constricts or dilates in response to increases or decreases in systemic BP.
In fact, poor glomerular perfusion and ischemia (obliterative preglomerular vascular changes) may play an important role in the pathogenesis of the described phenomenon.
In a rat model, the sustained preglomerular vasoconstrictive effect of serotonin caused ischemic interstitial nephritis (21).