As emotions heighten, the prefrontal lobe
is essential to controlling them, and serotonin is a necessary mechanism for this process to work effectively.
Tang and colleagues  studied the default mode network (DMN) in patients with early-onset schizophrenia (12 to 19 years old); they found increased functional connection between the ventromedial prefrontal lobe
and the right inferior temporal gyrus, left angular gyrus, and dorsomedial prefrontal lobe
, but decreased functional connection between the right angular gyrus and the cerebellar tonsil, left superior frontal gyrus and right inferior semilunar lobule.
The term Dysexecutive Syndrome (Baddeley, 1986), refers to a similar clinical-frame to what was previously described as Prefrontal Lobe
Syndrome, characterized by disorder in the planning and organizing of actions, problem-solving, and selective attention.
New research in America suggests it lies just behind the forehead in the brain's left prefrontal lobes
13) In general, tumors that involve the olfactory bulb, olfactory tract, or prefrontal lobe
can cause olfactory deficits, while temporal lobe tumors are associated with olfactory hallucination.
Overall the findings support the hypothesis that OCD is associated with structural changes of gray and white matter in the prefrontal lobe
, striatum, and thalamus.
As a matter of fact, the prefrontal lobes
maintain extensive connections, particularly with other cortical areas, the limbic system, the cortical and subcortical motor areas, and the sensory cortex (Damasio & Anderson, 2003).
In the experiment, brain scans of 103 volunteers from the US Military Academy at West Point, ranging in rank from officer cadet to major, found that neural networks in the frontal and prefrontal lobes
of those deemed 'leaders' were different from the rest.
In studies that have evaluated risk in people with bipolar disorder with and without cannabis use disorder, those who use cannabis have an earlier age of onset of bipolar disorder and earlier age at first hospitalization for bipolar disorder; in one study, adolescents with bipolar disorder and cannabis use disorder had more abnormalities in the prefrontal lobes
and temporal and subcortical structures, than those with bipolar disorder only (J.
287) (8) argue that 'repression' is therefore consonant with a short-circuiting of this process, so that repressed information is information that is excluded from the overarching network of executive control exercised by the prefrontal lobes
Importantly, elaborate momentary confabulations often involve damage to ventromedial prefrontal lobes
and the diencephalon, while the behaviorally spontaneous confabulations involve damage to the posterior orbitofrontal cortex or related anterior limbic structures.
Their underdeveloped prefrontal lobes
prevent them from thinking about the long-term consequences of their actions.