preclinical toxicology (prēˈ·kliˑ·ni·k
l t
ksˈ··kˑ·l·jē),
l tksˈ··kˑ·l·jē),n studies of the toxicology of a substance on animals and cells to prepare parameters for Phase I human subject clinical studies. These include determination of acute, subacute, and chronic toxicity, carcinogenicity, mutagenicity, teratogenicity, and effects on the reproductive system.
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