preclinical study

preclinical study

Any of the animal studies that provide the science behind human Phase-1 safety and tolerance studies, which must comply with good laboratory practice (GLP).

Data about a drug's activities and effects in animals informs boundaries for safe use of the drug in subsequent human testing (clinical studies or trials).
References in periodicals archive ?
pSivida to receive US$990k for three months exclusive negotiation rights and additional preclinical study
announced today that results from a preclinical study of GX15-070 in mantle cell lymphoma (MCL) cell lines and ex vivo patient samples showed that GX15-070 and bortezomib (Velcade) exhibit synergistic activity, due to the ability of GX15-070 to potently antagonize the Bcl-2 family member, Mcl-1.
Abstract 2502: A preclinical study evaluating the effects of GX15-070 on rituximab activity, in which in vitro exposure of rituximab-sensitive cell lines (RSCL) Raji and RL to GX15-070 resulted in a dose-dependent decrease in DNA synthesis and increase in apoptosis.
In addition, in a preclinical study (abstract 1995), SGN-33 was shown to bind to CD33 and block cytokine production by monocytes and macrophages.
Preclinical Study Shows that Fibrin Patch Offers an Easy, Rapid and Effective Method to Stop High Pressure Arterial Bleeding
NASDAQ: OXGN, XSSE: OXGN) today announced the publication of the results of a preclinical study evaluating the combination of vascular disrupting agents (VDAs) with an antiangiogenic drug to enhance suppression of tumor growth in mice, which appears in today's issue of the journal Science.
This is the first report of adipose stem and regenerative cells as a treatment for ischemic-related coronary artery disease in a randomized large animal preclinical study," said Dr.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 concerning the preclinical study results for CRx-401, its plans for further research and development of the Company's CRx-401 research program, its plans with respect to the research and development of the other product candidates in its portfolio and its drug discovery technology.
NASDAQ:CYTX) (Frankfurt:XMPA) announced today that adipose stem and regenerative cells, when administered in combination with a fat graft, improved survival of the transplanted tissue in a preclinical study.
announced today the results of a preclinical study evaluating GX15-070 both as a monotherapy and in combination with the proteasome inhibitor bortezomib (Velcade(R)) for the treatment of mantle cell lymphoma (MCL).
So far, each preclinical study has given Samaritan hope that SP233 holds promise to exert neuroprotective properties against beta-amyloid toxicity.
Although it is early stage, each preclinical study we accomplish gives us hope that we might have an extraordinary treatment for the mind robbing disease of Alzheimer's," stated Dr.