Duangporn Jamsai, PhD, Monash University RBM5 is a critical regulator of pre-mRNA
splicing and a lung tumor suppressor
Antisense technology involves the synthesis of a strand of nucleic acid that would bind to an mRNA or to a splicing site on pre-mRNA
and inactivates it effectively.
Furthermore, FUS is implicated in the regulation of gene promoter activity (17), is involved in pre-mRNA
splicing (18), and shuttles between the nucleus and the cytoplasm bound to RNA (19).
Among their topics are molecular mechanisms of heterogeneous nuclear ribonucleoproteins and their implications for human pathology, the role of SR and SR-related proteins in pre-mRNA
splicing, RNA-binding proteins in fungi and their role in mRNA localization, RNA binding domains and RNA recognition by RNA-editing machineries, and from structure to function of RNA binding domains.
These small RNAs block gene expression through multiple RNA interference (RNAi) pathways, including two newly discovered pathways in which small RNAs bind to Argonaut proteins or other forms of RNA present in the cell nucleus, such as long non-coding RNAs and pre-mRNA
RNA-binding proteins have a major role in every aspect of RNA biology, from transcription, pre-mRNA
splicing and polyadenylation to RNA modification, transport, localisation, translation and turnover .
won the Avanti Young Investigator Award in Lipid Research for his work on lipid signaling pathways regulating alternative pre-mRNA
processing and eicosanoid biosynthesis.
Stable alteration of pre-mRNA
splicing patterns by modified U7 small nuclear RNAs.
Gunderson suggests that combining both capabilities in the same molecule can enable the U1 Adaptor to inhibit the pre-mRNA
maturation step of polyA tail addition in a gene specific manner.
Influenza virus NS1 protein inhibits pre-mRNA
splicing and blocks mRNA nucleocytoplasmic transport.
RNA segments called exons carry the protein-making information, while the segments between exons, called introns, are snipped out of pre-mRNA
by special proteins.
The standard neo-Darwinian or neo-Weismann model (implied, never directly stated) is that some form of pre-mRNA
synthesis using the DNA of the genes as templates is ongoing in germ cells themselves, producing multiple RNA 'copies' of a gene.