pragmatic trial


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pragmatic trial

A clinical trial that measures effectiveness (i.e., the degree of beneficial effect of a drug or intervention in real clinical practice) by testing a full range of patients—with variable compliance, co-morbidities and polypharmacy—who might be treated with the drug or intervention. If an intervention has a significant beneficial effect in a pragmatic trial, then it has been shown not only that it can work, which reflects the results of a so-called explanatory trial, but also that it does work.

pragmatic trial

A trial to evaluate the effectiveness of a treatment investigated under real-world conditions, rather than during the application of stringent exclusion criteria.
See also: trial
References in periodicals archive ?
Explanatory trials deal with efficacy, whereas pragmatic trials are more closely associated with effectiveness.
An alternative might be to develop additional items more directly linked to the CONSORT Work Group on Pragmatic Trials recommended reporting criteria (Zwarenstein et al.
Use of controls, alternative trial designs and pragmatic trials in children by Dr Ian Wong and Dr Vincent Yeung
uses its extensive, applied database and real-world health care experience to assist pharmaceutical and medical device companies in the design, recruitment, and completion of clinical trials including retrospective and prospective pragmatic trials.