pragmatic trial


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pragmatic trial

A clinical trial that measures effectiveness (i.e., the degree of beneficial effect of a drug or intervention in real clinical practice) by testing a full range of patients—with variable compliance, co-morbidities and polypharmacy—who might be treated with the drug or intervention. If an intervention has a significant beneficial effect in a pragmatic trial, then it has been shown not only that it can work, which reflects the results of a so-called explanatory trial, but also that it does work.

pragmatic trial

A trial to evaluate the effectiveness of a treatment investigated under real-world conditions, rather than during the application of stringent exclusion criteria.
See also: trial
References in periodicals archive ?
Many however, may be less familiar with the two principal forms of randomised clinical trial: pragmatic trials and explanatory trials.
New studies should be pragmatic trials or high-quality prospective multisite observational studies and employ methods to minimize bias to the greatest extent possible.
to give appropriate weight to health services methods such as pragmatic trials and observations methods," according to Wardle and Oberg.
DaVita Clinical Research uses its applied database and healthcare experience to assist pharmaceutical and medical device companies in the design, recruitment, and completion of clinical trials including retrospective and prospective pragmatic trials.
Some have argued that there is an important need for more practical or pragmatic trials tested under more representative conditions (Tunis, Stryer, and Clancey 2003; Glasgow et al.
From its inception, EBM scholars have advocated the design and performance of large pragmatic trials with patient-important outcomes and have provided guidelines to apply the results to individual patients (5,7,8).