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practolol

   Also found in: Wikipedia 0.02 sec.
practolol
a β-adrenergic blocking agent with the same actions as propranolol.
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Exactly this situation existed when the FDA prohibited physicians from prescribing practolol and alprenolol even though large clinical studies indicated that these drugs could reduce the mortality rate of heart attack patients by 40 percent.
Assessing the FDA via the Anomaly of Off-Label Drug Prescribing by TABARROK, ALEXANDER T. / Independent Review
acebutolol, atenolol, labetalol, metoprotolol, oxprenolol, pindolol, practolol, and propranolol) * Captopril * Carbamazine * Cimetidine * Diphenylhydantoin (phenytoin) * Ethosuximide * Methimazole * Penicillamine * Phenazine * Quinidine From: The Bulletin on the Rheumatic Diseases, copyright 1991.
Lupus Erythematosus by Pamphlet by: Nat'l Inst. of Arthritis and Musculoskeletal & Skin Diseases
There are many variations on this story: isoproterenol inhalers, used to relieve asthma, caused 3500 deaths in England and Wales in the sixties; practolol, an anti-hyper-intensive, caused a number of cases of permanent or near-permanent blindness in England in the seventies.
The case for (some) regulation by Shenk, Joshua Wolf / Washington Monthly
 
 
 
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