RPL554-induced CFTR activity was further increased by the CFTR potentiator
Kalydeco (ivacaftor, VX770) suggesting additional potential benefit by the drug combination.
A CFTR potentiator
in patients with cystic fibrosis and the G551D mutation.
Synereca's lead program will combine a potentiator
with Colistin (polymyxin E, colistimethate sodium) for the treatment of serious hospital-associated infections caused by resistant Gram-Negative bacteria, a $2.
GLPG1837 is expected to start Phase 1 in 2014.
Ivacaftor, known as a CFTR potentiator
, keeps the CFTR protein channels on the cell surface open longer to increase the flow of salt and water into and out of the cell.
Alcohol itself is a known potentiator
of iron absorption (Olynyk 2005) though to what extent this relationship exists is unknown.
The Vertex drug, taken orally twice a day, is a CFTR potentiator
PCR targets included a 16S rDNA segment and a macrophage infectivity potentiator
(mip) gene fragment of L.
The most accurate identification of species can be obtained by sequence analysis of the macrophage infectivity potentiator
(mip) gene (14).
VX-770: Phase 3 Registration Program Ongoing Three trials of the novel CFTR potentiator
VX-770 are ongoing as part of a global Phase 3 registration program focused on patients with the G551D mutation.
Humans have been using soy in conjunction with traditional chemotherapy for some time as a chemo potentiator
," said Suter.
Talin[R] all natural flavor enhancer/sweetness potentiator