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Hypersensitivity to the particular potassium-sparing diuretic.
NSAIDs - ibuprofen (Motrin, Advil), naproxen (Aleve and others) when taken long-term and daily for arthritis or other problems, potassium-sparing diuretics (spironolactone and others), potassium supplementation, ACE inhibitors (Capoten, Vasotec, Zestril, and others), angiotensin-II receptor antagonists (Cozaar, Diovan, Avapro, and others), aldosterone antagonists, and heparin.
Those with heart failure who were taking potassium-sparing diuretics had significantly lower rates of hospitalization and death from worsening heart failure, as well as lower cardiac event rates, than those who were taking non-potassium-sparing diuretics (J.
POTASSIUM-SPARING DIURETICS All potassium-sparing diuretics have a weak antihypertensive effect when used by themselves.
Three small nonrandomized studies found that spironolactone was more effective than potassium-sparing diuretics in hypertensive patients with primary aldosteronism.
NSAIDs-ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve, and others) when taken long-term and daily for arthritis or other diseases or conditions, Potassium-sparing diuretics (spironolactone and others), Potassium supplementation, ACE inhibitors (Capoten, Vasotec, Zestril, and others), angiotensin-II receptor antagonists (Cozaar, Diovan, Avapro, and others), aldosterone antagonists, and heparin.
Serum potassium levels should be monitored and potassium-sparing diuretics should not be used during Prograf therapy (see PRECAUTIONS).
Medications that may increase serum potassium include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDs.
Use caution when prescribing ANGELIQ to women who regularly take other medications that can increase potassium, such as NSAIDs, potassium-sparing diuretics, potassium supplements, ACE inhibitors, angiotensin-II receptor antagonists, and heparin.